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  • Research Publications

CRTP Trainees and CRTP Alumni are bold; BHCRI members underlined

Adding some "splice" to stress eating: autophagy, ESCRT and alternative splicing orchestrate the cellular stress response
Elias Habib, Allyson Cook, Sabateeshan Mathavaraj, Graham Dellaire
(2021) Genes (Basel)
PMID: 34440370

A 2-year prospective analysis of insomnia as a mediator of the relationship between androgen deprivation therapy and perceived cognitive function in men with prostate cancer
Sheila N Garland, Josee Savard, Sarah L Eisel, Richard J Wassersug, Nicholas J Rockwood, John Thoms, Heather SL Jim, Brian D Gonzalez
(2021) Cancer
PMID: 34411294

The polysaccharide chitosan facilitates the isolation of small extracellular vesicles from multiple biofluids
Awanit Kumar, Surendar Reddy Dhadi, Ngoc-Nu Mai, Catherine Taylor, Jeremy W Roy, David A Barnett, Stephen M Lewis, Anirban Ghosh, Rodney J Ouellette
(2021) J Extracell Vesicles
PMID: 34478244

Recent advances in the transition metal catalyzed synthesis of quinoxalines: a review
Vipin K. Maikhuri, Ashok K. Prasad, Amitabh Jha and Smriti Srivastava
(2021) New Journal of Chemistry

Lipoprotein lipase hydrolysis products induce pro-inflammatory cytokine expression in triple-negative breast cancer cells
Alexandria J Tobin, Nicholas P Noel, Sherri L Christian, Robert J Brown
(2021) Research Note

A comprehensive analysis of SNPs and CNVs identifies novel markers associated with disease outcomes in colorectal cancer
Yajun Yu, Salem  Werdyani, Megan Carey, Patrick Parfrey, Yildiz E Yilmaz, Sevtap Savas
(2021) Mol Oncol
PMID: 34309201

Role of dietary antioxidants in p-53 mediated cancer chemoprevention and tumor suppression
JP Jose Merlin, HP Vasantha Rupasinghe, Graham Dellaire, Kieran Murphy
(2021) Oxid Med Cell Longev
PMID: 34257824

An examination of the role of socioeconomic status in the relationship between depression and prostate cancer survivorship in a population-based sample of men from Atlantic Canada
Gabriela Ilie, Robert Rutledge, Ellen Sweeney
(2021) Oncology
PMID: 33486485

Triple-negative breast cancer and the COVID-19 pandemic: clinical management perspectives and potential consequences of infection
Justin Brown, Marie-Claire Wasson, Paola Marcato
(2021) Cancers (Basel)
PMID: 33467411

Post-administration dosimetry in Yttrium-90 radioembolization through micro-CT imaging of radiopaque microspheres in a porcine renal model
E. Courtney Henry, Matthew Strugari, George Mawko, Kimberly D. Brewer, Robert Abraham, S. Cheenu Kappadath, Alasdair Syme
(2021) Phys Med Biol
PMID: 33784639

The missing Lnc: the potential of targeting triple-negative breast cancer and cancer stem cells by inhibiting long non-coding RNAs
Justin Brown, Marie-Claire Wasson, Paola Marcato
(2021) Cells
PMID: 32244924

Plasmin and plasminogen system in the tumor microenvironment: Implications for cancer diagnosis, prognosis and therapy
Alamelu G. Bharadwaj, Ryan W Holloway, Victoria A. Miller, David M. Waisman
(2021) Cancers (Basel)
PMID: 33921488

Tumor levels of the mediators of ErbB2-driven anoikis resistance correlate with breast cancer relapse in patients receiving trastuzumab-based therapies
Alexi Surette, Byong Hoon Yoo, Tallal Younis, Kara Matheson, Tarek Rameh, Jaime Snowdon, Gillian Bethune, Kirill V. Rosen
(2021) Breast Cancer Res Treat
PMID: 33728523

Addressing the dark matter of gene therapy: technical and ethical barriers to clinical application
Kateryna Kratzer, Landon J. Getz, Thibaut Peterlini, Jean-Yves Masson, Graham Dellaire
(2021) Hum Genetics
PMID: 33834266

An in vivo genome-wide shRNA screen identifies BCL6 as a targetable biomarker of paclitaxel resistance in breast cancer
Mohammad Sultan, Jacob T. Nearing, Justin M. Brown, Thomas T. Huynh, Brianne M. Cruickshank, Emily Lamoureaux, Dejan Vidovic, Margaret L. Dahn, Wasundara Fernando, Krysta M. Coyle, Carman A. Giacomantonio, Morgan G.I. Langille, Paola Marcato
(2021) Mol Oncol
PMID: 33932086

Lncrna part 1 promotes proliferation and migration, is associated with cancer stem cells, and alters the miRNA landscape in triple-negative breast cancer
Brianne M. Cruickshank, Marie-Claire D. Wasson, Justin M. Brown, Wasundara Fernando, Jaganathan, Venkatesh, Olivia L. Walker, Fiorella Morales-Quintanilla, Margaret L. Dahn, Dejan Vidovic, Cheryl A. Dean, Carter VanIderstine, Graham Dellaire, Paola Marcato
(2021) Cancers (Basel)
PMID: 34072264

N-nitrosoethylenethiourea formation at environmentally-relevant concentrations of ethylenethiourea in a pooled groundwater sample
Crystal L. Sweeney, Yuri Park, Dreenan A. Shea, Jong Sung Kim
(2021) Sci Total Environ
PMID: 33243502

LncRNA — miRNA axes in breast cancer: Novel points of interaction for strategic attack
Jaganathan Venkatesh, Marie-Claire D Wasson, Justin M. Brown, Wasundara Fernando, Paola Marcato
(2021) Cancer Lett
PMID: 33848519

Nurse navigators“ views on patient and system factors associated with navigation needs among women with breast cancer
Sally D. Miller, Robin Urquhart, George Kephart, Yukiko Asada, Tallal Younis
(2021) Curr Oncol
PMID: 34198915

Role of Myeloid Cells in Oncolytic Reovirus-Based Cancer TherapyMast cells and skin and breast cancers: a complicated and microenvironment-dependent role
Mark Hanes, Carman Giacomantonio, Jean Marshall
(2021) Cells
PMID: 33922465

Vishnupriyan Kumar, Michael Giacomantonio, Shashi Gujar
(2021) Viruses
PMID: 33920168

A multi-parametric extraction method for Vn96-isolated plasma extracellular vesicles and cell-free DNA that enables multi-omic profiling
Jeremy Roy, Catherine A Taylor, Annie Beauregard, Surendar Dhadi, D Craig Ayre, Sheena Fry, Simi Chako, Gabriel Wajnberg, Andrew P Joy, Ngoc-Nu Mai-Thi, Nicolas Crapoulet, David A Barnett, Anirban Ghosh, Stephen M Lewis, Rodney J Ouellette
(2021) Sci Rep
PMID: 33850235
Jeremy Roy and Craig Ayre are CRTP Alumni. Jeremy is now a BHCRI Associate Member.

Natural killer T cell immunotherapy combined with oncolytic vesicular stomatitis virus or reovirus treatments differentially increases survival in mouse models of ovarian and breast cancer metastasis
Simon GebremeskelAdam Nelson, Brynn Walker, Tora Oliphant, Lynnea Lobert, Douglas Mahoney, Brent Johnston
(2021) J Immunother Cancer

Basement membrane degeneration is common in lichenoid mucositis with dysplasis
Iris Lin, Denise M Laronde, Lewei Zhang, Miriam P Rosin, Ilena Yim, Leigha D. Rock
(2021) Can J Dent Hyg
PMID 33643413
Rationale and protocol for a randomized waitlist controlled trial of videoconference delivered cognitive behaviour therapy for insomnia (CBT-I) to improve perceived cognitive impairment (PCI) among cancer survivors
Sheila Garland, Josee Savard, Katheryn Dalton, Nyissa Walsh, Melanie Seal, Joshua Rash, Sondria Browne, Robin Urquhart, John Thoms, Veeresh Gadag, Kara Laing
(2021) Contemp Clinical Trials
PMID: 33588077
Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy
Prathyusha Konda, Liubov M Lifshits, John A Roque3rd, Houston D Cole, Colin G Cameron, Sherri A McFarland, Shashi Gujar
(2020) Oncoimmunology
PMID: 33457082
Transcriptome modulation following administration of luteolin to bleomycin-etoposide-cisplatin chemotherapy on rat LC540 tumor Leydig cells
Ha Tuyen Nguyen, Roxanne Couture, Mohamed Touaibia, Luc J Martin
(2021) Andrologia
PMID: 33400304

Factors associated with cognitive impairment during the first year of treatment for nonmetastatic breast cancer
Nicole Rodriguez, Jonathan M Fawcett, Joshua A Rash, Renee Lester, Erin Powell, Connor D. MacMillan, Sheila Garland
(2021) Cancer Med
PMID: 33455070
NK cell infiltration is associated with improved overall survival in solid cancers: A systematic review and meta-analysis
Sarah Nersesian, Sarah Schwartz, Stephanie Grantham, Leah MacLean, Stacey Lee, Morgan Pugh-Toole, Jeanette Boudreau
(2021) Transl Oncol
PMID: 33186888
Quality of life among survivors of adolescent and young adult cancer in Canada: A Young Adults with Cancer in Their Prime (YACPRIME) study
Fiona SM Schult, Karine Chalifour, Geoff Eaton, Sheila Garland
(2020) Cancer
PMID: 33332603
MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes
Vipin Shankar Chelakkot, Kaiwen Liu, Ema Yoshioka, Shaykat Saha, Danyang Xu, Maria Licursi, Ann DorwardKensuke Hirasawa
(2020) Scientific Reports
PMID: 33335181

Metabolism and pharmacokinetics of a novel polyphenol fatty acid ester phloridzin docosahexaenoate in Balb/c female mice
Wasundara FernandoKerry GoralskiDavid W HoskinHP Vasantha Rupasinghe
(2020) Scientific Reports
PMID: 33288802

S100A10 has a critical regulatory function in mammary tumor growth and metastasis: Insights using MMTV-PyMT oncomice and clinical patient sample analysis
Alamelu G. BharadwajMargaret L. Dahn, Rong-Zong Liu, Patricia Colp, Lynn N. Thomas, Ryan WHolloway, Paola A. Marignani, Catherine KL Too, Penelope J. Barnes, Rosaline Godbout, Paola Marcato and David M. Waisman
(2020) Cancers

Peptide-Affinity Precipitation of Extracellular Vesicles and Cell-Free DNA Improves Sequencing Performance for the Detection of Pathogenic Mutations in Lung Cancer Patient Plasma
Catherine Tayler, Simi Chacko, Michelle Davey, Jacynthe Lacroix, Alexander MacPherson, Nicholas Finn, Gabriel WajnbergAnirban Ghosh, Nicolas Crapoulet, Stephen M LewisRodney J Ouellette
(2020) Int J Mol Sci
PMID: 33260345

Cytokines in oncolytic virotherapy
Jonathan G Pol, Samuel T Workenhe, Prathyusha Konda, Shashi Gujar, Guido Kroemer
Cytokine Growth Factor Rev
PMID: 33183957

Raloxifene prevents stress granule dissolution, impairs translational control and promotes cell death during hypoxia in glioblastoma cells
Kathleen M AttwoodAaron Robichaud, Lauren P Westhaver, Elizabeth L Castle, David M Brandman, Aruna D Balgi, Michel Roberge, Patricia Colp, Sidney Croul, Inhwa Kim, Craig McCormickJennifer A CorcoranAdrienne Weeks
(2020) Cell Death Dis
PMID: 33203845

NK cell infiltration is associated with improved overall survival in sold cancers: A systematic review and meta-analysis
Sarah Nersesian, Sarah L Schwartz, Stephanie R Grantham, Leah K MacLeanStacey N Lee, Morgan Pugh-Toole, Jeanette E Boudreau
(2021) Translational Oncology

Trastuzumab-induced upregulation of a protein set in extracellular vesicles emitted by ErbB2-positive breasat cancer cells correlates with their trastuzumab sensitivity”
Arik Drucker, Byong Hoon Yoo, Iman Aftab Khan, Dongsic Choi, Laura Montermini, Xiaoyang Liu, Sanja Jovanovic, Tallal YounisKirill V Rosen.
(2020) Breast Cancer Res
PMID: 33023655

Regulation of Nrf2/ARE pathway by dietary flavonoids: a friend or foe for cancer management?
Tharindu L SuraweeraVasantha RupasingheGraham DellaireZhaolin Xu
(2020) Antioxidants (Basel)
PMID: 33050575

Humanized zebrafish enhance human hematopoietic stem cell survival and promote acute myeloid leukemia clonal diversity
Vinothkumar Rajan, Nicole Melong, Wing Hing Wong, Benjamin King, R. Spencer Tong, Nitin Mahajan, Daniel Gaston, Troy Dund, David Rittenberg, Graham Dellaire, Clinton JV Campbell, Todd Druley and Jason N Berman.
(2020) Haematologica
PMID: 21857359

Material properties of disulfide-crosslinked hyaluronic acid hydrogels influence prostate cancer cell growth and metabolism
Nicky Tam, Dudley Chung, Samuel James Baldwin, Jeffrey R Simmons, Lingling Xu, Jan K RaineyGraham Dellaire and John Frampton
(2020) Journal of Materials Chemistry B

Expression, purification, and refolding of diverse class IB hydrophobins
Calem Kenward, Kathleen L. Vergunst, David N. Langelaan
(2020) Protein Expression and Purification
PMID: 32866612

Cyanidin-3-O-Glucoside-rich haskap berry administration suppresses carcinogen-induced lung tumorigenesis in A/JCr Mice
Madumani AmararathnaDavid W HoskinHP Vasantha Rupasinghe
(2020) Molecules
PMID: 32842605

Myeloid-derived suppressor cell depletion therapy targets IL-17A-expressing mammary carcinomas
Bassel Dawod, Jinghua LiuSimon GebremeskelChi Yan, Antonia Sappong, Brent JohnstonDavid W HoskinJean S MarshallJun Wang
(2020) Sci Rep
PMID: 32770025

Anti-cancer potential of cannabinoids, terpenes and Flavonoids present in cannabis
Tomko, AM, Whynot, EG, Ellis, LD, Dupre, DJ
(2020) Cancers
PMID: 32708138

Repurposing CD8+T cell Immunity against SARS-CoV-2 for cancer immunotherapy: a positive aspect of the COVID-19 pandemic?
Gujar, S., Pol, JG., Kim, Y., Kroemer, G
(2020) OncoImmunology

PML Isoform Expression and DNA Break Location Relative to PML Nuclear Bodies Impacts the Efficiency of Homologous Recombination
Kathleen M AttwoodJayme Salsman, Dudley Chung, Sabateeshan Mathavarajah, Carter Van Iderstine, Graham Dellaire
(2020) Biochem Cell Biol
PMID: 31671275

Regulation of Epithelial-to-Mesenchymal Transition by Alternative Translation Initiation Mechanisms and its Implications for Cancer Metastasis
Amit Bera, Stephen M Lewis
(2020) Int J Mol Sci
PMID: 32517298

An Exploration of the Impact of Cognitive Behavioural Therapy of Insomnia (CBT-I) on Perceived Cognitive Impairment in Breast Cancer
N WalshS Garland, R Lester, J McCarthy, K Laing
(2020) Sleep

Exploring the Impact of Cognitive Behavioral Therapy for Insomnia (CBT-I) on Daytime Productivity in Survivors of Breast Cancer
J Kiely, N WalshJ McCarthy, E Powell, SN Garland
(2020) Sleep

Cellular Stress Orchestrates the Localization of hnRNP H to Stress Granules
Michael L Wall, Amit Bera, Florence K Wong, Stephen M Lewis
(2020) Exp Cell Res
PMID: 32473225

Anthocyanin-rich Haskap (Lonicera Caerulea L.) Berry Extracts Reduce Nitrosamine-Induced DNA Damage in Human Normal Lung Epithelial Cells in Vitro
M AmararathnaDW HoskinHP Vasantha Rupasinghe
(2020) Food and Chemical Toxicology
PMID: 32413456

The experiences of young adults living with metastatic/advanced cancer: A scoping Review
Drake, EK and Urquhart, R
J Adolesc Young Adult Oncol
PMID: 31692403

Singh, P., Zeng, X., Chen, X., Yang, Y., Chen, Y., Cui, S., Carrier, A., Oakes, K., Luan, T., Zhang, X.
Quantitation of polymeric-microneedle-delivered HA15 in tissues using liquid chromatography-tandem
mass spectrometry
(2020) Journal of Pharmaceutical and Biomedical Analysis, 185, art. no. 113230.

Giacomantonio, M.A., Sterea, A.M., Kim, Y., Paulo, J.A., Clements, D.R., Kennedy, B.E., Bydoun,
M.J., Shi, G., Waisman, D.M., Gygi, S.P., Giacomantonio, C.A., Murphy, J.P., Gujar, S.
Quantitative Proteome Responses to Oncolytic Reovirus in GM-CSF-and M-CSF-Differentiated Bone
Marrow-Derived Cells
(2020) Journal of Proteome Research, 19 (2), pp. 708-718.
PMID: 31884793

Slade, L., Biswas, D., Ihionu, F., El Hiani, Y., Kienesberger, P.C., Pulinilkunnil, T.
A lysosome independent role for TFEB in activating DNA repair and inhibiting apoptosis in breast
cancer cells
(2020) Biochemical Journal, 477 (1), pp. 137-160.
PMID: 31820786

Chen, Y., Yang, Y., Xian, Y., Singh, P., Feng, J., Cui, S., Carrier, A., Oakes, K., Luan, T., Zhang, X.
Multifunctional Graphene-Oxide-Reinforced Dissolvable Polymeric Microneedles for Transdermal
Drug Delivery
(2020) ACS Applied Materials and Interfaces, 12 (1), pp. 352-360.  

Konda, P., Murphy, J.P., Gujar, S.
Improving MHC-I ligand identification by incorporating targeted searches of mass spectrometry data
(2020) Methods in Molecular Biology, 2120, pp. 161-171.
PMID: 32124318

Kennedy, B.E., Sadek, M., Elnenaei, M.O., Reiman, A., Gujar, S.A.
Targeting NAD+ Synthesis to Potentiate CD38-Based Immunotherapy of Multiple Myeloma
(2020) Trends in Cancer, 6 (1), pp. 9-12.
PMID: 31952784

Portales-Cervantes, L., Crump, O.M., Dada, S., Liwski, C.R., Gotovina, J., Haidl, I.D., Marshall, J.S.
IL-4 enhances interferon production by virus-infected human mast cells
(2020) Journal of Allergy and Clinical Immunology,
PMID: 32112794

Sterea, A.M., El Hiani, Y.
The Role of Mitochondrial Calcium Signaling in the Pathophysiology of Cancer Cells
(2020) Advances in Experimental Medicine and Biology, 1131, pp. 747-770.
PMID: 31646533

Arias, M., Haney, E.F., Hilchie, A.L., Corcoran, J.A., Hyndman, M.E., Hancock, R.E.W., Vogel, H.J.
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin
(2020) Biochimica et Biophysica Acta - Biomembranes, art. no. 183228
PMID: 32126228

Kennedy, B.E., Sadek, M., Gujar, S.A.
Targeted Metabolic Reprogramming to Improve the Efficacy of Oncolytic Virus Therapy
(2020) Molecular Therapy
PMID: 32243836

Guisier, F., Barros-Filho, M.C., Rock, L.D., Strachan-Whaley, M., Marshall, E.A., Dellaire, G., Lam,
Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment
(2020) Advances in Experimental Medicine and Biology, 1224, pp. 35-51
PMID: 32036603
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