Supervisor:
Co-Supervisor:
Dr. Lee Ellis
Program of Study:
Masters, Pharmacy
Project Title:
Synergistic Effects of Jadomycin B and Cyclooxygenase 2 Inhibition on Breast Cancer Metastasis
Lay Research Summary:
Breast cancer is the most common female cancer in Canada, becoming deadly when the cells move
to new areas of the body, forming new tumors. This is a concern with triple negative breast cancer,
which lack proteins that are found in other forms of breast cancer. The absence of these proteins
makes triple negative breast cancer very hard to treat, being unable to respond to certain
medications, leading to poor outcomes. The goal of our project is to understand the effects a natural
compound, jadomycin B, found to kill triple negative breast cancer cells. The effect of jadomycin
B is improved when given with a drug, celecoxib, that blocks pathways of inflammation. We will
test combinations of these two drugs on human triple negative breast cancer cells that have been
grown as well as after they have been injected into young zebrafish to form tumors. This research
will advance our understanding of jadomycin B as an anticancer agent and how it can be used to
treat triple negative breast cancer.
Location:
Dalhousie University