Appointments:
Professor, Dalhousie University
Department of Pathology & Laboratory Medicine
Division of Anatomical Pathology
Research Interests:
Neuro-Oncology, Glioma Genetics
I am a diagnostic Neuropathologist with research interest in both biobanking and molecular diagnostics of brain tumors.
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- As a Biobanker, I teamed up with Dr. Zhaolin Xu to create the NSHA-Dalhousie Biobank. The QEII Foundation provided start-up funding for this first institutional Biobank and I am currently seeking additional grant funds. In its first year, the Biobank has grown significantly and currently contains collections of lung, breast, nervous system, pancreatic and hematologic malignancies. I look forward to the Biobank’s continued growth both in the quantity of specimens in the current collections and the addition of new collections. The Biobank will provide significant opportunities for Canadian and international clinical research.
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- My experimental brain tumor research has profiled both adult gliomas and pediatric medulloblastomas. Currently, I am developing a next generation sequencing chip capable of detecting major molecular abnormalities in a glioma as a single assay. I hope that the novel test will establish NSHA as a reference testing center for gliomas within the next year.
Involvement with BHCRI to date:
Dr. Sidney E. Croul is an Associate Member
Phone:
(902) 473-3156
Email:
Contact:
Room 635-B, 6th Floor, DJ Mackenzie Building 5788 University Avenue Halifax, NS B3H 1V8
Publications:
Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.Clin Cancer Res. 2015 Aug 15;21(16):3750-8
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer Cell. 2014 Mar 17;25(3):393-405
Analysis of IDH mutation, 1p/19q deletion, and PTEN loss delineates prognosis in clinical low-grade diffuse gliomas. Neuro Oncol. 2014 Jan 26
Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis Lancet Oncol. 2013 Nov;14(12):1200-7
Canonical TGF-β pathway activity is a predictor of SHH-driven medulloblastoma survival and delineates putative precursors in cerebellar development. Brain Pathol. 2013 Mar;23(2):178-91