Appointments:
Professor, Department of Applied Oral Sciences, Faculty of Dentistry; Associate Dean Research & Graduate Studies, Faculty of Dentistry
Cross-Appointments: School of Biomedical Engineering, Department of Radiology
Dalhousie University
Research Interests:
Biomaterials, biomedical devices, drug delivery
Novel and Potentially Multifunctional Chemotherapeutic Delivery Vehicles
Our research program is focused on the development of novel biomaterials and biomedical devices, with an emphasis on polyphosphate processing approaches that facilitate localized delivery of therapeutic agents, including anticancer drugs. Targeted applications include hepatocellular carcinoma (liver cancer), a challenging and often palliative condition for which chemotherapeutic agent delivery directly to the location of the tumor (and minimizing its impact on noncancerous cells) is being considered in conjunction with blocking of the tumor’s blood supply.
Involvement with BHCRI to date:
Dr. Mark Joseph Filiaggi is an Associate Member
Phone:
902-494-7102
Email:
Website:
uniweb.dal.ca/members/994/profile
Contact:
Room 5192 Dentistry Building, 5981 University Avenue, PO Box 15000, Halifax, NS B3H 4R2
Publications:
Nix, A Momeni, D Chevrier, C Whitman and MJ Filiaggi, Doxorubicin-loaded polyphosphate glass microspheres for transarterial chemoembolization, J Biomed Mater Res B: Appl Biomat 2020; 108B(6): 2621-2632.
I Gibson, A Momeni and MJ Filiaggi, Minocycline-loaded calcium polyphosphate glass microspheres as a potential drug delivery agent for the treatment of periodontitis, J Appl Biomat Func 2019, July-September: 1-9.
EM Valliant and MJ Filiaggi, Impact of trivalent ions additions on the stability and cohesion of calcium polyphosphate coacervates for embolization applications, J Biomed Mater Res B: Appl Biomat 2019, 107B: 2638–2648.
J Doucet, E Tonkopi, A Nuschke, ML Tremblay, K Brewer, S Beyea, M Filiaggi, R Abraham, U Werner-Zwanziger, D Boyd. Multi-modal imageability and degradation characteristics of high-borate glass systems for transient embolization, J Non-Crystal Solids 2019, 510: 26-35.
PA Comeau and MJ Filiaggi, A two-stage cold isostatic pressing and gelling approach for fabricating a therapeutically loaded amorphous calcium polyphosphate local delivery system, Journal of Biomaterials Applications 2017; 32(1): 126-136.
C Pierlot, L Kiri, K MacDonald, B Dickey, E Valiant, M Chagnon, M Assad, MJ Filiaggi, and D Boyd. A pilot evaluation of an aluminum-free glass ionomer cement using a sub-chronic osseous defect model in New Zealand white rabbits, submitted Materials Letters 2016, 184:301-304.
EM Valliant, BT Dickey, R Price, D Boyd, and MJ Filiaggi. Fourier transform infrared spectroscopy as a tool to study the setting reaction in glass-ionomer cements, Materials Letters 2016, 185: 256-259.
Y Hu, R Pilliar, M Grynpas, R Kandel, U Werner-Zwanziger, M Filiaggi. Phase transformations during processing and in vitro degradation of porous calcium polyphosphates, Journal of Materials Science: Materials in Medicine 2016, 27(7):117.
A Momeni and MJ Filiaggi, Degradation and hemostatic properties of polyphosphate coacervates, Acta Biomaterialia 2016, 41: 328-341.
A Momeni, M Filiaggi. Rheology of polyphosphate coacervates. Journal of Rheology 2016, 60(1): 25-34.