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  • Wasundara Fernando, PhD

Supervisor:

Dr. David Hoskin

Program of Study:

Postdoctoral fellow

Project Title:

Cytoprotective and chemopreventive activities of phytochemicals and their derivatives

Scholarships and/or Awards:

  • First place in oral presentations, Dalhousie Postdoctoral research day 2018
  • Second place in BHCRI CRTP 3MT 2018
  • Cancer Research Training Program (CRTP) Traineeship Awards 2017, 2015 and 2014
  • John and Lina Graham Commonwealth Scholarship, 2015
  • First place in oral presentations, Graduate Research Day, 2014

Career Aspirations:

Wasu’s research interest continues to be in the field of Natural Product Chemistry and investigation of pharmacological activities of phytochemicals and their derivatives. Wasu obtained her BSc degree in Pharmacy from the University of Colombo, Sri Lanka, and MSc and PhD degrees from Dalhousie University. Currently, Wasu is working as a postdoctoral fellow at the Department of Pathology, Dalhousie University. Her research explores the cytoprotective and chemopreventive activities of phytochemicals and their derivatives.

Location:

Dalhousie University

Publications:

Fernando, W., Rupasinghe, H. P. V. and Hoskin, D. W. (2019). Dietary phytochemicals with anti-oxidant and pro-oxidant activities: A double-edged sword in relation to adjuvant chemotherapy and radiotherapy? Cancer Lett., (In press).

Almasi, S., Sterea, A.*, Fernando, W.*, Clements, D., Marcato, P., Hoskin, D. W., Gujar, S., and El Hiani, Y. (2019). TRPM2 ion channel promotes gastric cancer migration, invasion and tumor growth through the AKT signaling pathway. Sci. Rep., Sci. Rep., 9, 4182.
*Contributed equally.

Greenshields, A. L., Fernando, W., and Hoskin, D. W. (2019). The anti-malarial drug artesunate causes cell cycle arrest and apoptosis oftriple-negative MDA-MB-468 and HER2-enriched SK-BR-3 breast cancercells. Exp. Mol. Pathol. 107, 10-22.

Knickle, A., Fernando, W., Greenshields, A. L., Rupasinghe, H. P. V. and Hoskin, D. W. (2018). Myricetin-induced apoptosis of triple-negative breast cancer cells is mediated by the iron-dependent generation of reactive oxygen species from hydrogen peroxide. Food Chem.Toxicol. 6 (118), 154-167. 

Fernando, W., Coombs, M. R. P., Hoskin, D. W. and Rupasinghe, H. P. V. (2016). Docosahexaenoic acid-acylated phloridzin, a novel polyphenol fatty acid ester derivative, is cytotoxic to breast cancer cells. Carcinogenesis, 37(10), 1004–1013. 

Fernando, W., Rupasinghe, H. P. V. and Hoskin, D. W. (2015). Regulation of hypoxia-inducible factor-1a and vascular endothelial growth factor signaling by plant flavonoids. Mini-Rev. Med. Chem., 15, 479-489. 

Fernando, W. and Rupasinghe, H. P. V. (2013). Anticancer properties of phytochemicals present in medicinal plants of North America. In: Using Old Solutions to New Problems - Natural Drug Discovery in the 21st Century. (Ed.) Marianna Kulka. InTech - Open Access Publisher. Rijeka, Croatia. ISBN: 978-953-51-1158-0. pp. 159-180.

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