Dr. Sherri L. Christian, PhD
Assistant Professor, Department of Biochemistry
Cross-appointed to Faculty of Medicine
Memorial University of Newfoundland
Regulation of cell fate decisions by signaling pathways
My lab is interested in the regulation of cell survival by the receptor CD24 (also known as heat stable antigen). In general, CD24 is expressed at higher levels in highly proliferating, undifferentiated progenitor cells with reduced or absent expression in fully mature and differentiated cells. In colorectal and some breast cancer cells, CD24 promotes proliferation and is associated with increased cancer metastasis. In contrast, CD24 promotes apoptosis in Burkitt’s lymphoma and acute lymphoblastic leukemia. Understanding how CD24 regulates these dramatically different cell fates will advance our understanding of how cell survival and proliferation is mis-regulated in cancer.