Dr. Sherri L. Christian, PhD
Assistant Professor, Department of Biochemistry
Cross-appointed to Faculty of Medicine
Memorial University of Newfoundland
Regulation of cell fate decisions by signaling pathways
My lab is interested in the regulation of cell survival by the receptor CD24 (also known as heat stable antigen). In general, CD24 is expressed at higher levels in highly proliferating, undifferentiated progenitor cells with reduced or absent expression in fully mature and differentiated cells. In colorectal and some breast cancer cells, CD24 promotes proliferation and is associated with increased cancer metastasis. In contrast, CD24 promotes apoptosis in Burkitt’s lymphoma and acute lymphoblastic leukemia. Understanding how CD24 regulates these dramatically different cell fates will advance our understanding of how cell survival and proliferation is mis-regulated in cancer.
Involvement with BHCRI to date:Dr. Christian is a BHCRI Senior Scientist and has served as both a panelist and scientific officer on a BHCRI Scientific Review Committee. As a PDF, Dr. Christian was a CRTP Award recipient.
Contact:SN-3013/4019, Science building, Memorial University of Newfoundland, 232 Elizabeth Ave, St. John's, NL CANADA A1B 3X9
Pallegar, NK (nee Kendyala), Ayre, DC, and Christian, SL* (2015) Repression of CD24 expression by oncogenic Ras/Raf or Ras/PI3K is relieved by inhibition of Raf but not MEK or PI3K. Frontiers in Cell and Developmental Biology. 3:47 doi: 10.3389/fcell.2015.00047
Ayre, DC, Elstner, M, Smith, NC, Moores, ES, Hogan, AM, and Christian, SL* (2015) Immature B cells Dynamically Regulate CD24 Expression and Release CD24-Containing Microvesicles Following Antibody Stimulation. Immunology. In Press. DOI: 10.1111/imm.12493
Komatsu, Y, Hirasawa, K., and Christian SL* (2015) Global gene analysis identifying genes commonly regulated by the Ras/Raf/MEK and type I IFN pathways. Genomics Data. 4: 84-87. DOI: 10.1016/j.gdata.2015.03.012
Smith, NC, Fairbridge, NA, and Christian, SL* (2015) Dynamic upregulation of CD24 in pre-adipocytes promotes adipogenesis. Adipocyte. 4(2):89-100. Published online: 15 Dec 2014
Komatsu, Y, Christian, SL, Ho, N, Pongnopparat, T, Licursi, M, and Hirasawa, K. (2014) Oncogenic Ras inhibits IRF1 to promote viral oncolysis. Oncogene. DOI: 10.1038/onc.2014.331
Christian, SL*, Rasley, BT, Roe, T, Moore, JT, Harris, MB and Drew, KL (2014) Habituation of Arctic ground squirrels (Urocitellus parryii) to handling and movement during torpor to prevent artificial arousal. Frontiers in Integrative Physiology. DOI: 10.3389/fphys.2014.00174
Christian, SL*, Zu, D, Licursi, M, Komatsu, Y, Pongnopparat, T, Codner, DA, Hirasawa, K* (2012) Suppression of IFN-induced transcription underlies IFN defects generated by activated Ras/MEK in human cancer cells. PlosONE. 7(9): e44267 *Corresponding authors
Dave, K.R, Christian, SL, Perez-Pinzon, MA, Drew, KL. (2012) Neuroprotection: lessons from hibernators (Review). Comparative Biochemistry and Physiology Part B: Biochemistry & Molecular Biology. 162:1-9.
Licursi, M, Christian, SL, Hirasawa, K. (2011) In vitro and in vivo comparison of viral and cellular IRESs for bicistronic vector expression. Gene Therapy. 3 March 2011; doi: 10.1038/gt.2011.11.
Christian, SL, Collier, TW, Zu D, Licursi, M, Hough, CM, and Hirasawa, K. (2009) Downregulation of STAT2 mediates the Ras/Raf/MEK pathway-induced inhibition of the IFN-alpha antiviral response. Journal of Virology. 83: 6717-26