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  • Dr. Sherri L. Christian, PhD

Appointments:

Assistant Professor, Department of Biochemistry
Cross-appointed to Faculty of Medicine

Affiliations:

Memorial University of Newfoundland

Research Interests:

Regulation of cell fate decisions by signaling pathways

My lab is interested in the regulation of cell survival by the receptor CD24 (also known as heat stable antigen). In general, CD24 is expressed at higher levels in highly proliferating, undifferentiated progenitor cells with reduced or absent expression in fully mature and differentiated cells. In colorectal and some breast cancer cells, CD24 promotes proliferation and is associated with increased cancer metastasis. In contrast, CD24 promotes apoptosis in Burkitt’s lymphoma and acute lymphoblastic leukemia. Understanding how CD24 regulates these dramatically different cell fates will advance our understanding of how cell survival and proliferation is mis-regulated in cancer. 

Involvement with BHCRI to date:

Dr. Christian is a BHCRI Senior Scientist and has served as both a panelist and scientific officer on a BHCRI Scientific Review Committee. As a PDF, Dr. Christian was a CRTP Award recipient.

Phone:

(709) 864-8550

Contact:

SN-3013/4019, Science building, Memorial University of Newfoundland, 232 Elizabeth Ave, St. John's, NL CANADA A1B 3X9
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