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  • Rahimeh Rasouli, PhD

Supervisor:

Dr. Marya Ahmed

Program of Study:

Postdoctoral Fellow

Project Title:

Dual siRNA loaded nanoparticles for Breast Cancer Treatment

Research Summary:

siRNA is considered as a potent therapeutic agent because of its high specificity and efficiency in suppressing genes that are overexpressed during disease development. For nearly two decades, many studies have been done to bring the siRNA technology into clinical applications. However, only a few successes has been reported to date, largely due to the lack of an efficient delivery system to carry siRNA into the cancer cells' cytosol where RNA interference takes place. Among the different nanocarriers for siRNA delivery, peptides are popular because of their structural and functional diversity. A variety of peptides have been investigated for their ability to translocate siRNA into living cells via different mechanisms. In this project, we aim to develop peptide nanocarriers for precise loading of two siRNA and study their gene knockdown efficacies and tumor regression capabilities in HER2+ breast cancer cell lines and tumor-bearing mouse models. Besides, due to their biodegradable nature, peptide scaffolds provide an ideal carrier for delivery of siRNA in in-vitro and in-vivo and can be considered safe for their further translation into clinical settings.

Career Aspirations:

I am a biomedical investigator with a multidisciplinary background in nanomedicine, biotechnology, and cancer cellular biology. My specific research interest design and develop new nano-based therapies for the prevention/treatment of life-threatening conditions such as cancers and other incurable diseases. As a cancer researcher, I hope my discoveries can make a real difference for people with cancer. It is rewarding to help achieve new treatments for patients.

Location:

University of Prince Edward Island

Publications:

Rasouli, Rahimeh, et al. "99mTc-anionic linear globular dendrimer-G2-phenylalanine conjugate: Novel brain tumor SPECT imaging." Biointerface Research in Applied Chemistry 11.4 (2021): 11244-11255.

Rasouli, Rahimeh, and Niloofar Nazeri. "Glioma and Exosome." (2021).

Adebileje, T., Rasouli, R., Amani, A., & Faridi-Majidi, R. (2021). Moving Boundary Model to Estimate Diffusion Coefficient and Viscosity of Dextran Coated Magnetic Iron-Oxide Using Capillary Electrophoresis. Acta Scientific MEDICAL SCIENCES (ISSN: 2582-0931), 5(8).

Fathi, S., Saber, R., Adabi, M., Rasouli, R., Douraghi, M., Morshedi, M., & Farid-Majidi, R. (2021). Novel competitive voltammetric aptasensor based on electrospun carbon nanofibers-gold nanoparticles modified graphite electrode for Salmonella enterica serovar detection. Biointerface Research in Applied Chemistry, 8702-8715. 

Rasouli, Rahimeh, et al. "Preparation and Evaluation of New LAT1-Targeted USPION to Improve Sensitivity and Specificity in Metabolic Magnetic Imaging of Breast Cancer." (2020).

Rasouli, Rahimeh, Ahmed Barhoum, and Hasan Uludag. "A review of nanostructured surfaces and materials for dental implants: surface coating, patterning and functionalization for improved performance." Biomaterials science 6, no. 6 (2018): 1312-1338.

Shafaghi M, Maktoobian S, Rasouli R, Howaizi N, Ofoghi H, Ehsani P. Transient Expression of Biologically Active Anti-rabies Virus Monoclonal Antibody in Tobacco Leaves. Iranian Journal of Biotechnology. 2018 Apr;16(1)

Rasouli, R., Barhoum, A., Bechelany, M., & Dufresne, A. (2018). Nanofibers for Biomedical and Healthcare Applications. Macromolecular bioscience, 1800256.

"99mTc-Anionic Linear Globular Dendrimer–G2-Phenylalanine Conjugate: Novel Brain Tumor SPECT imaging"  Rahimeh Rasouli, Mahmood Alaei-Beirami, Farzaaneh Zaaeri, Nasim Hashempour Alamdari, Hassan Ebrahimi Shahmabadi, Ahmad Bitarafan Rajabi, Amir Darbandi-Azar, Mehdi Shafiee Ardestani 2018.

Rasouli, R., Saffari, M., Ebrahimi, S. E. S., Asaadi, A., & Shafiee, M. Gd 3-Asparagine Anionic Linear Globular Dendrimer Second Generation G2 Complexes: Novel Nano-Biohybrid Theranostics.  Contrast Media & Molecular Imaging · September 2017

Book Chapters:

Rasouli, R., & Barhoum, A. (2019). Advances in nanofibers for antimicrobial drug delivery. Handbook of Nanofibers, 733-774. 

Barhoum, A., Rasouli, R., Yousefzadeh, M., Rahier, H., & Bechelany, M. (2018). Nanofiber Technology: History and Developments. Handbook of Nanofibers, 1-42.

Rasouli, R., Alaei-Beirami, M., & Zaaeri, F. (2018). Nanobased Cns Delivery Systems. In Nanobiomaterials (pp. 441-473). Apple Academic Press.

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