Appointments:
Scientific Director, Beatrice Hunter Cancer Research Institute
Associate Professor, Department of Microbiology and Immunology; cross-appointed to the Department of Pathology
Affiliations:
Dalhousie University
Research Interests:
Natural Killer cells, NK immunogenetics, cancer gene and expression profiling, bioinformatics
Precision natural killer cell therapy
Cancer results when mutations in a person’s DNA drive uncontrolled growth of a population of cells. Therefore, even with many common features, cancer is a unique disease in each patient. The Boudreau laboratory is defining the features of tumours that result from genetic mutations that can be targeted by a population of white blood cells called natural killers (NK), aiming to develop NK cells as precise effectors for immunotherapy.
Involvement with BHCRI to date:
Dr. Jeanette Boudreau is a BHCRI Associate Member. She is the supervisor of five CRTP trainees and is a member of the BHCRI Training Committee.
Phone:
(902) 494 4536
Email:
Website:
medicine.dal.ca/departments/department-sites/microbiology/people/our-faculty/jeanette-boudreau.html
Contact:
Sir Charles Tupper Medical Building, Dalhousie University, 5850 College Street, P.O. Box 15000, Halifax, Nova Scotia, Canada B3H 4R2
Publications:
Westhaver LP, Nersesian S, Nelson A, MacLean LK, Carter EB, Rowter D, Wang J, Gala-Lopez BL, Stadnyk AW, Johnston B, Boudreau JE. Mitochondrial damage-associated molecular patterns trigger arginase-dependent lymphocyte immunoregulation. Cell Rep. 2022 May 24;39(8):110847.
Pugh-Toole M, Nicolela AP, Nersesian S, Leung BM, Boudreau JE. Natural killer cells: The missing link in effective treatment for high-grade serous ovarian carcinoma. Curr Treat Options Oncol 2022 Feb;23(2):210-226.
Nersesian S, Lee SN, Grantham S, Meunier L, Communal L, Arnason T, Arnold D, Nelson BH, Mes-Messon AM, Boudreau JE. CD16ahigh NK cell infiltration and spatial relationships with T cells and macrophages can predict improved progression-free survival in high grade ovarian cancer. Medrxiv, preprint.
Nersesian S, Schwartz SL, Grantham SR, MacLean LK, Lee SN, Pugh-Toole M, Boudreau JE.NK cell infiltration is assocaited with improved overall survival in solid cancers: A systematic review and meta-analysis. Translational Oncology 2021 Jan;14(1):100930.
Hargreaves BKV, Roberts S, Derfalvi B, Boudreau JE. Highly Efficient Serum-Free Manipulation of miRNA in Human NK Cells Without Loss of Viability or Phenotypic Alterations Is Accomplished With TransIT-TKO. Plos ONE 2020 Apr 17;15(4):e0231664.
Savoy SKA, Boudreau JE. The evolutionary arms race between virus and NK cells: diversity enables population-level virus control. Viruses, 2019 17;11(10) pii. E959.
Nersesian S, Glazebrook H, Toulany J, Grantham S, Boudreau JE. Naturally killing the silent killer: NK cell-based immunotherapy for ovarian cancer. Frontiers in Immunology. 2019 9;10:1782.