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  • Naeimeh Jafari, PhD

Supervisor:

Dr. Brendan M. Leung

Program of Study:

Postdoctoral Fellow, Applied Oral Science

Project Title:

The oral microbiome impact on chemotherapy-induced oral mucositis (CIOM)

Scholarships and/or Awards:

  • Suraj Maurao Prize, Poster award MOOT32, 2019

Career Aspirations:

I intend to be part of the cancer-related research field to understand the underlying mechanism and learn new techniques. I want to study the interaction of microbes and mammalian cell lines to capture microbes' impacts on cell lines related to cancers.  

Location:

Dalhousie University

Publications:

McNicholl, E. T., Das, R., SilDas, S., Byun, J. A., Akimoto, M., Jafari, N., & Melacini, G. (2021). Backbone resonance assignment of the cAMP-binding domains of the protein kinase A regulatory subunit Iα. Biomolecular NMR Assignments, 1-4.

Jafari, N., Del Rio, J., Akimoto, M., Byun, J.A., Boulton, S., Moleschi, K., Alsayyed, Y., Swanson, P., Huang, J., Pomier, K.M. and Lee, C., 2021. Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations. Proceedings of the National Academy of Sciences, 118(21).

Algamal, M., R. Ahmed, N. Jafari, B. Ahsan, J. Ortega, and Giuseppe Melacini. "Atomic-resolution map of the interactions between an amyloid inhibitor protein and amyloid beta (Aβ) peptides in the monomer and protofibril states." Journal of Biological Chemistry (2017): jbc-M117.

Ahmed, R., B. VanSchouwen, N. Jafari, X. Ni, J. Ortega, and G. Melacini. "Molecular mechanism for the (−)-epigallocatechin gallate-induced toxic to nontoxic remodeling of Aβ oligomers." Journal of the American Chemical Society 139, no. 39 (2017): 13720-13734.

Jafari, N., R. Ahmed, M. Gloyd, J. Bloomfield, P. Britz-McKibbin, and G. Melacini. "Allosteric sensing of fatty acid binding by NMR: Application to human serum albumin." Journal of medicinal chemistry 59, no. 16 (2016): 7457-7465.

Algamal, M., J. Milojevic, N. Jafari, W. Zhang, and G. Melacini. "Mapping the interactions between the alzheimer’s aβ-peptide and human serum albumin beyond domain resolution." Biophysical Journal 105, no. 7 (2013): 1700-1709.

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