Farideh Badichi Akher, PhD
Supervisor:Dr. Jan Rainey
Program of Study:Postdoctoral Fellow
Project Title:Engineering of recombinant spider silk-based fusion proteins with specific functionality to sequester target bioactive proteins
As a computational chemist, for the last five years, I have been developing my skills and abilities on cancer research. I’m energetic, enthusiastic, and thrive in challenging situations and I would like to continue to develop my skills and experience by working in a changing, dynamic environment. I have strong leadership skills and communication skills that I would like to continue developing. This will help me achieve my goal of leading production teams in the future.
Abdolkarim Farrokhzadeh, Farideh Badichi Akher, Timothy J. Egan, Molecular Mechanism Exploration of Potent Fluorinated PI3K Inhibitors with a Triazine Scaffold: Unveiling the Unusual Synergistic Effect of Pyridine-to-Pyrimidine Ring Interconversion and CF3 Defluorination, The Journal of Physical Chemistry B, (2021), accepted.
Abdolkarim Farrokhzadeh, Ali Reza Modarresi-Alam, Farideh Badichi Akher, Erich Kleinpeter and Uwe Schilde, Investigation of the unusually high rotational energy barrier about the C-N bond in 5-(2-x-phenyl)-N,N-dimethyl-2H-tetrazole-2-carboxamides: Insights from dynamic 1H-NMR and DFT calculations, Journal of Molecular Structure, (2021), Accepted.
Abdolkarim Farrokhzadeh, Farideh Badichi Akher, Fisayo A. Olotu, Fanie R. Van Heerden, How does HEC72702 chirality affect the selective inhibition of hepatitis B virus capsid dimer?, Chemical biology and drug design, (2020), Accepted, doi.org/10.1111/cbdd.13771.
Farideh Badichi Akher*, Abdolkarim Farrokhzadeh, Neil Ravenscroft and Michelle M. Kuttel, Mechanistic Study of Potent Fluorinated EGFR Kinase Inhibitors with a Quinazoline Scaffold against L858R/T790M/C797S Resistance Mutation: Unveiling the Fluorine Substituents Cooperativity Effect on the Inhibitory Activity, The Journal of Physical Chemistry B, 124 (2020), 5813–5824.
Farideh Badichi Akher*, Abdolkarim Farrokhzadeh, Neil Ravenscroft and Michelle M. Kuttel, A Mechanistic Study of a Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitor against L858R/T790M Resistance Mutation, Biochemistry, 15 (2019) 4246-4259.
Abdolkarim Farrokhzadeh, Farideh Badichi Akher, Bahareh Honarparvar and Fanie R. Van Heerden, Modulation of stacking interaction found between cytosine molecule in the active site of HIV-integrase and subestituted-methylbenzen as a part of inhibitors: Physical nature of the position and substituent effects, Molecular Structure 5 (2019) 126950.
Farideh Badichi Akher*, Abdolkarim Farrokhzadeh, Pritika Ramharack, Letitia Shunmugam and Mahmoud E. S. Soliman, Identification of Two Natural Flavonoids as Antiviral Candidate against Hepatitis C Virus NS5B Polymerase, journal of Medical Hypotheses, 132 (2019), 109359.
Abdolkarim Farrokhzadeh, Farideh Badichi Akher, Fisayo A. Olotu, Fanie R. Van Heerden and Mahmoud E.S. Soliman, Revealing the distinct mechanistic binding and activity of 5-(1-(3,5-Dichloropyridin-4-yl)ethoxy)-3-(5-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)-1H-indazole enantiomers against FGFR1, Submitted to the journal of Physical Chemistry Chemical Physics, 21 (2019) 15120.
Farideh Badichi Akher, Abdolkarim Farrokhzadeh, Fisayo A. Olotu, Clement Agoni and Mahmoud E.S. Soliman, The irony of chirality – Unveiling the distinct mechanistic binding and activities of 1-(3-(4-Amino-5-(7-methoxy-5-methylbenzo[b]thiophen-2-yl)-7H-pyrrolo[2,3- d]pyrimidin-7-yl)pyrrolidin-1-yl)prop-2-en-1-one enantiomers as irreversible covalent FGFR4 inhibitors, Organic & Biomolecular Chemistry, 17 (2019) 1176-1190.
Farideh Badichi Akher*, Abdolkarim Farrokhzadeh, and Mahmoud E.S. Soliman, Covalent Vs Non-Covalent inhibition: Tackling Drug Resistance in EGFR – A Thorough Dynamic Perspective, chemistry & biodiversity, 16 (2019) 1800518.