Dr. Xianping Dong, PhD
Associate Professor, Department of Physiology and Biophysics
Dalhousie University Faculty of Medicine
ion channel and transporters, calcium signalling, autophagy, lysosomes, lysosomal storage disease, cancer, neurodegenerative disease, bacterial infection.
My primary research interests include lysosome physiology and lysosome-related diseases. Specifically, we study lysosomal ion channels and transporters in cancer progression, lysosomal storage diseases, neurodegenerative diseases and bacterial infection.
Membership Status:Dr. Dong is a BHCRI Associate Member
Address:4C1, Sir Charles Tupper Medical Bldg, 5850 College Street, Halifax, Nova Scotia, Canada B3H 4R2
Sun X, Yang Y, Zhong XZ, Cao Q, Zhu XH, Zhu X, Dong XP. A negative feedback regulation of mTORC1 activity by the lysosomal Ca2+ channel TRPML1 using a calmodulin-dependent mechanism. Autophagy, 2018;14(1):38-52.
Cao Q, Yang Y, Zhong XZ, Dong XP. The lysosomal Ca2+ release channel TRPML1 regulates lysosome size by activating calmodulin. J Biol Chem. 2017; 292(20):8424-8435.
Zhong XZ, Zou Y, Sun X, Dong G Sr, Cao Q, Pandey A, Rainey JK, Zhu X, Dong XP. Inhibition of TRPML1 by lysosomal adenosine involved in severe combined immunodeficiency diseases. J Biol Chem. 2017; 292(8):3445-3455
Zhong XZ, Sun X, Cao Q, Dong G, Schiffmann R, Dong XP. BK channel agonist represents a potential therapeutic approach for lysosomal storage diseases. Sci Rep. 2016; 6:33684.
Zhong XZ, Cao Q, Sun X, Dong XP. Activation of lysosomal P2X4 by ATP transported into lysosomes via SLC17A9 using V-ATPase generated voltage gradient as the driving force. J Physiol. 2016; 594(15):4253-66.
Cao Q, Zhong XZ, Zou Y, Murrell-Lagnado R, Zhu MX, and Dong XP. Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion. J Cell Biol, 2015; 209(6):879-94.
Cao Q, Zhong XZ, Zou Y, Zhang Z, Ligia T, Dong XP. BK Channels Alleviate Lysosomal Storage Diseases by Providing Positive Feedback Regulation of Lysosomal Ca2+ Release. Dev Cell, 2015; 33(4):427-41.
Cao Q, Zhao K, Zhong XZ, Zou Y, Yu H, Huang P, Xu TL, Dong XP. SLC17A9 Protein Functions as a Lysosomal ATP Transporter and Regulates Cell Viability. J Biol Chem, 2014; 289(33):23189-99.
Huang P, Zou Y, Zhong XZ, Cao Q, Zhao K, Zhu MX, Murrell-Lagnado R, Dong XP. P2X4 Forms Functional ATP-activated Cation Channels on Lysosomal Membranes Regulated by Luminal pH. J Biol Chem, 2014; 289(25):17658-67.
Dong XP*, Shen D*, Wang X*, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman L, Delling M, and Xu H. PI(3,5)P2 controls intracellular membrane traffic by direct activation of mucolipin Ca2+ release channels in the endolysosome. Nature Commun, 2010, 1: 38.