Dr. H.P. Vasantha Rupasinghe, Ph.D, P.Ag
Associate Professor and Canada Research Chair (Fruit Bioactives & BioProducts)
Faculty of Agriculture, Dalhousie University
Faculty of Medicine, Dalhousie University
Faculty of Engineering, Dalhousie University
Faculty of Science, University of Auckland, New Zealand
Anti-cancer properties of plant secondary metabolites; Design and synthesis of anti-cancer drug candidates from natural compounds.
Investigating anti-cancer properties of plant flavonoids and their derivatives
Polyphenols such as flavonoids found in fruits and vegetables possess antioxidative and anti-proliferative effects which appear to contribute to their chemopreventive activity. Dr. Rupasinghe’s research program is investigating whether the isolated flavonoids can be used as anti-cancer therapeutic candidates. Current investigations are also include understanding the mechanism(s) of action of specific flavonoids and their derivatives that have shown selective detrimental action on cancer cell lines but minimum cytotoxicity to cultured normal human cells.