Dr. H.P. Vasantha Rupasinghe, Ph.D, P.Ag
Associate Professor and Canada Research Chair (Fruit Bioactives & BioProducts)
Faculty of Agriculture, Dalhousie University
Faculty of Medicine, Dalhousie University
Faculty of Engineering, Dalhousie University
Faculty of Science, University of Auckland, New Zealand
Anti-cancer properties of plant secondary metabolites; Design and synthesis of anti-cancer drug candidates from natural compounds.
Investigating anti-cancer properties of plant flavonoids and their derivatives
Polyphenols such as flavonoids found in fruits and vegetables possess antioxidative and anti-proliferative effects which appear to contribute to their chemopreventive activity. Dr. Rupasinghe’s research program is investigating whether the isolated flavonoids can be used as anti-cancer therapeutic candidates. Current investigations are also include understanding the mechanism(s) of action of specific flavonoids and their derivatives that have shown selective detrimental action on cancer cell lines but minimum cytotoxicity to cultured normal human cells.
Involvement with BHCRI to date:Dr. Rupasinghe is a BHCRI Associate Member
Contact:Room 219-3 Cox Building, Dalhousie Agricultural Campus, 50 Pictou Road, Truro, NS, Canada, B2N 5E3
Caseya, S.C., A. Amedei, K. Aquilano, A.S. Azmi, F. Benencia, D. Bhakta, A.E. Bilsland, C.S. Boosani, S. Chen, M.R. Ciriolo, S. Crawford, H. Fujii, A.G. Georgakilas, G. Guha, D. Halicka, W.G. Helferich, P. Heneberg, K. Honoki, W.N. Keith, S.P. Kerkar, S.I. Mohammed, E. Niccolai, S. Nowsheen, H.P.V. Rupasinghe, A. Samadi, N. Singh, W.H. Talib, V. Venkateswaran, R.L. Whelan, and X. Yang. 2015. Cancer prevention and therapy through the modulation of the tumor microenvironment – A review. Seminars in Cancer Biology. (On line: doi:10.1016/j.semcancer.2015.02.007).
Samadi, A.K., A. Bilsland, A.G. Georgakilas, A.S. Azmi, A. Amedei, A. Amin, A. Bishayee, B.L. Lokeshwar, B. Grue, C. Panis, C.S. Boosani, D. Poudyal, D.M. Stafforini, D. Bhakta, E. Niccolai, G. Guha, H.P.V. Rupasinghe, H. Fujii, K. Honoki, K. Mehta, K. Aquilano, L. Lowe, L.J. Hofseth, L. Ricciardiello, M.R. Ciriolo, N. Singh, R.L. Whelan, R. Chaturvedi, S.S. Ashraf, and H.M.C.S. Kumara. 2015. A multi-targeted approach to suppress tumor-promoting inflammation – A review. Seminars in Cancer Biology. (On line: doi:10.1016/j.semcancer.2015.03.006).
Arumuggam, N., N.A. Bhowmick, and H.P.V. Rupasinghe. 2015. A review: Phytochemicals targeting JAK/STAT signaling and IDO expression in cancer. Phytotheraphy Research. 29:805-817.
Fernando. W., D.W. Hoskin, and H.P.V. Rupasinghe. 2015. Regulation of hypoxia-inducible factor-1α and vascular endothelial growth factor signaling by plant flavonoids. Mini-reviews in Medicinal Chemistry. 15:479-489.
Potter, E., M. Jha, K. Bhullar, H.P.V. Rupasinghe, J. Balzarini, and A. Jha. 2015. Investigation of fatty acid conjugates of 3,5-bisarylmethylene-4-piperidone derivatives as antitumor agents and human topoisomerase-IIα inhibitors. Journal of Bioorganic Chemistry. 23:411-421.
Sudan, S. and H.P.V. Rupasinghe. 2014. Flavonoid-enriched apple fraction induces cell cycle arrest, DNA topoisomerase II inhibition and apoptosis in human liver cancer HepG2 cells. Nutrition and Cancer. 66:1237-1246.
Paul, N.K., K.S. Bhullar, H.P.V. Rupasinghe, J. Balzarinic, and A. Jha. 2014. All trans 1-(3-arylacryloyl)-3,5-bis(pyridin-4-ylmethylene)piperidin-4-ones as curcumin-inspired antineoplastics. European Journal of Medicinal Chemistry. 87:461-470.
Nair, S.V.G., Ziaullah, and H.P.V. Rupasinghe. 2014. Fatty acid esters of phloridzin induce apoptosis of human liver cancer cells through altered gene expression. PLoS ONE 9(9): e107149.
Nair, S.V.G., M. Hettihewa, and H.P.V. Rupasinghe. 2014. Apoptotic and inhibitory effects on cell proliferation of hepatocellular carcinoma HepG2 cells by methanol leaf extract of Costus speciosus. BioMed Research International. Volume 2014 e-Article ID 627098. 10 Pages. DOI 10.1155/2014/637098.
Sudan, S. and H.P.V. Rupasinghe. 2014. Quercetin-3-O-glucoside induces human DNA topoisomerase II inhibition, cell cycle arrest and apoptosis in hepatocellular carcinoma cells. Anti-cancer Research. 34:1691-1699.