Dr. Stephen Westcott, PhD Chemistry
Professor and Canada Research Chair
Adjunct Professor, Université Laval and at UNB
Mount Allison University, Université Laval and UNB
Synthesis, chemistry, boron, capsaicin, gingerol
Designing New Anticancer Compounds. Our research focuses on the design and synthesis of new bio-inspired compounds based on natural products, such as capsaicin (hot peppers) and ginergol (ginger). We are incorporating non-toxic boron groups into these new compounds as boron is known to selectively target cancer cells while leaving healthy cells intact.
Involvement with BHCRI to date:Dr. Westcott is a BHCRI Associate Member
Contact:Barclay Building, 63C York Street, Sackville, NB E4L 1G8
Invited Editorial on Boron Chemistry ‘Hot peppers for a healthier future: boron-containing capsaicinoids’ Westcott, S. A.* Future Med. Chem. 2013, 5, 613
‘Boron Compounds as anti-tuberculosis agents’ Campbell-Verduyn, L. S.; Bowes, E. G.; Li, H.; Vallée, A. M.; Vogels, C. M.; Decken, A.; Gray, C. A.;*
Westcott, S. A.* Heteroatom Chem. Submitted.
Invited Paper to Celebrate the 100th Anniversary of the 1913 Nobel Prize in Chemistry to Alfred Werner ‘Rhodium complexes containing arylspiroborates
derived from 3,5-di-tert-butylcatechol and their use in catalyzed hydroborations’ Geier, M. J.; Geier, S. J.; Halcovitch, N. R.; Vogels, C. M.; Decken,
A.; Westcott, S. A.* Polyhedron 2013, 52, 1181-1189.
‘Synthesis and anticancer properties of bis(salicylaldiminato)platinum(II) complexes’ Patterson, A. E.; Miller, J. J.; Miles, B. A.; Stewart, E. L.;
Melanson, J.-M. E.; Vogels, C. M.; Decken, A.; Morin Jr., P.*; Westcott, S. A.* Bioorg. Med. Chem. Lett. 2013, 23, Manuscript in preparation.
‘Synthesis, characterization, and bioactivities of platinum(II) complexes bearing pyridinecarboxaldimines containing aliphatic groups’ Stewart, E. L.;
Patterson, A. E.; O'Neill,T.; Li, H.; Flewelling, A.; Vogels, C. M.; Decken, A.; Lloyd, V. K.;* Gray, C. A.;* Westcott, S. A.* Can. J. Chem. 2013, 91,
‘Synthesis and biological activities of arylspiroborates derived from 2,3-dihydroxynaphthalene’ Geier, M. J.; Bowes, E. G.; Lee, G. M.; O'Neill, T.; Li,
H.; Flewelling, A.; Vogels, C. M.; Decken, A.; Gray, C. A.;* Westcott, S. A.* Heteroatom Chem. 2013, 24, 116-123.
‘Synthesis, characterization and bioactivities of arylspiroborates derived from 4-tert-butylcatechol and 3,5-di-tert-butylcatechol’ Webb, M. I.;
Halcovitch, N. R.; Bowes, E. G.; Lee, G. M.; Geier, M. J.; Vogels, C. M.; O'Neill, T.; Li, H.; Flewelling, A.; Decken, A.; Gray, C. A.;* Westcott, S. A.*
J. Heterocyclic Chem. in press.
‘Pyridinones are not antioxidants as shown by kinetics of free radical autoxidation, but they prevent radical oxidations catalyzed by toxic heavy metals’
Ramsaywack, S.; Vogels, C. M.; Ricker, S. L.; Westcott, S. A.; Barclay, L. R. C.* Chem. Res. Toxicol. 2013, 26, 399-409.