Dr. Sevtap Savas, PhD
Associate professor, Discipline of Genetics (primary) and Discipline of Oncology (cross-appointment)
Faculty of Medicine, Memorial University of Newfoundland
My lab is interested in a) identification of prognostic markers in cancer with a current focus of genetic markers and colorectal cancer, and b) development of biological databases.
Survival Studies in Cancer
In collaboration with investigators from Newfoundland Colorectal Cancer Registry and other institutions, my lab focuses on candidate pathway and genomewide survival studies in colorectal cancer. Currently, we examine genetic variations, such as SNPs and copy number variations (CNVs), and their statistical associations with outcome risk (e.g. recurrence and death) in colorectal cancer. The overall aim in these projects is to understand the biology of variable survival outcomes among patients and to develop prognostic indices.
Involvement with BHCRI to date:Dr. Savas is a BHCRI Senior Scientist
Contact:300 Prince Philip Drive, HSC, Room 4333, St. John’s, NL, Canada A1B 3V6
Zhu Y, Wang PP, Savas S, Zhao J, Green R, Woods M, Sun Z, Roebothan B, Squires J, Buehler B, Dicks D, Zhao J, Campbell PT. Mclaughlin JR, Parfrey PS. Influence of Prediagnostic Cigarette Smoking on Colorectal Cancer Survival: Overall and by Tumor Molecular Phenotype. British Journal of Cancer 2014 Mar 4;110(5):1359-66.
Savas S, Liu G, Xu W. Special considerations in prognostic research in cancer involving genetic polymorphisms. BMC Medicine 2013, 11:149.
Tram E, Savas S, Ozcelik H. Missense variants of uncertain significance (VUS) altering the phosphorylation patterns of BRCA1 and BRCA2 PLOS ONE (2013) 8(5):e62468.
*Negandhi A, Hyde A, Dicks E, Younghusband B, Parfrey P, Green R, Savas S. MTHFR Glu429Ala and ERCC5 His46His polymorphisms are associated with prognosis in colorectal cancer patients: Analysis of two independent cohorts from Newfoundland. PLOS ONE (2013) 8(4): e61469.
Zhu Y, Wu H, Wang PP, Savas S, Woodrow J, Wish T, Jin R, Green R, Woods M, Roebothan B, Buehler S, Dicks E, Mclaughlin JR, Campbell PT, Parfrey PS. Dietary patterns and colorectal cancer recurrence and survival: a cohort study. BMJ Open 2013;3:e002270.
Eng L, Azad AK, Habbous S, Pang V, Xu W, Maitland-van der Zee AH, Savas S, Mackay H, Amir E, Liu G. Vascular endothelial growth factor pathway polymorphisms as prognostic and pharmacogenetic factors in cancer: A systematic review and meta-analysis. Clinical Cancer Research (2012) 18(17):4526-4537.
Savas S, Hyde A, Stuckless S, Parfrey P, Younghusband B, Green C. Serotonin transporter gene (SLC6A4) variations are associated with poor survival in colorectal cancer patients. PLoS ONE (2012) 7(7): e38953.
Savas S. A curated database of genetic markers from the angiogenesis/VEGF pathway and their relation to clinical outcome in human cancers. Acta Oncologica (2012) Feb;51(2):243-6.
Azad AK, Bairati I, Samson E, Cheng D, Mirshams M, Qiu X, Savas S, Waldron J, Wang C, Goldstein D, Xu W, Meyer F, Liu G. Validation of genetic sequence variants as prognostic factors in early stage head and neck squamous cell cancer survival. Clinical Cancer Research (2012) 18(1):196-206.
Azad AK, Bairati I, Samson E, Cheng D, Cheng L, Mirshams M, Savas S, Waldron J, Wang C, Goldstein D, Xu W, Meyer F, Liu G. Genetic sequence variants and the development of secondary primary cancers in patients with head and neck cancers. Cancer (2012) 118(6):1554-65.