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  • Dr. Paola Marcato - breast cancer, PhD

Appointments:

Associate Professor

Affiliations:

Department of Pathology, Dalhousie University

Research Interests:

Cancer, Breast Cancer

The research projects in my laboratory have the long-term goal of developing improved therapeutic strategies for breast cancer based on a precision medicine approach. We use transcriptome and genome-wide functional assays, cell lines, patient-derived xenografts (PDXs), mouse tumor models, and analysis of published patient datasets to identify biomarkers, study breast cancer stem cells (CSCs) and understand factors important in breast cancer progression. These factors include epigenetic modifications such as DNA methylation and long non-coding RNA.

The breast cancer projects in my laboratory have the long-term goal of developing improved therapeutic strategies for breast cancer based on a precision medicine approach. We utilize both transcriptome and methylome profiling, and genome-wide functional assays (e.g. shRNA screens) to identify biomarkers which predict response to therapies. Using a combination of breast cancer cell line panels, patient-derived xenografts (PDXs), mouse tumor models, and analysis of published patient datasets, the potential biomarkers are validated.

Currently recruiting graduate students and postdoctoral fellows

Involvement with BHCRI to date:

Dr. Marcato is a BHCRI Senior Scientist

Phone:

(902) 494-4239

Contact:

Department of Pathology, Dalhousie University, 11C1 5850 College Street, Halifax, NS, Canada, B3H 4R2
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