Dr. Neale Ridgway, MSc, PhD
Professor, Departments of Pediatrics and Biochemistry & Molecular Biology
Dalhousie University Faculty of Medicine: Director, Atlantic Research Centre
Membrane biogenesis, cholesterol regulation, phospholipid regulation, lipid transport proteins
Understanding the role of lipids in cell proliferation and survival
Lipids such as phospholipids and cholesterol are indispensible for membrane synthesis, cell signaling and energetics. Cell proliferation is dependent on lipid synthesis (termed lipogenesis) that doubles membrane content at each round of cell division. Rapidly proliferating cancer cells have increased lipogenesis as a result of activation of genes encoding biosynthetic enzymes and regulatory proteins. Our lab studies several of these lipogenic enzymes and transport proteins as potential targets for attenuating cancer cell proliferating and survival.