Dr. Neale Ridgway, MSc, PhD
Professor, Departments of Pediatrics and Biochemistry & Molecular Biology
Dalhousie University Faculty of Medicine: Director, Atlantic Research Centre
Membrane biogenesis, cholesterol regulation, phospholipid regulation, lipid transport proteins
Understanding the role of lipids in cell proliferation and survival
Lipids such as phospholipids and cholesterol are indispensible for membrane synthesis, cell signaling and energetics. Cell proliferation is dependent on lipid synthesis (termed lipogenesis) that doubles membrane content at each round of cell division. Rapidly proliferating cancer cells have increased lipogenesis as a result of activation of genes encoding biosynthetic enzymes and regulatory proteins. Our lab studies several of these lipogenic enzymes and transport proteins as potential targets for attenuating cancer cell proliferating and survival.
Involvement with BHCRI to date:Dr. Ridgway is a BHCRI Senior Scientist.
Contact:Atlantic Research Centre, Room C-306, CRC Building, Dalhousie University, 5849 University Avenue, P.O. Box 15000, Halifax, Nova Scotia, Canada B3H 4H7
M. Charman, T.R. Colbourne, A. Pietrangelo, L. Kreplak and N.D. Ridgway (2014) Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival. J. Biol. Chem. 289; 15705-15717.
C.M. Morton, A. Aitchison, K. Gehrig and N.D. Ridgway (2013) A mechanism for suppression of the CDP-choline pathway during apoptosis. J. Lipid Res. 54;3373-3384.
D.J. Arsenault, B.H. Yoo, K.V. Rosen, N.D. Ridgway (2013) ras-Induced upregulation of CTP:phosphocholine cytidylyltransferase α contributes to malignant transformation of intestinal epithelial cells. J. Biol. Chem. 288; 633-643.
N.D. Ridgway (2013). The role of phosphatidylcholine and choline metabolites to cell proliferation and survival. Critical Reviews in Biochemistry and Molecular Biology. 48; 20-38.
K. Gehrig, and N.D. Ridgway (2011) CTP:phosphocholine cytidylyltransferase α (CCTα) and lamins alter nuclear membrane structure without affecting phosphatidylcholine synthesis. Biochim. Biophys. Acta 1811; 377-385.