Dr. Michael Bezuhly, MD, MSc, SM, FRCSC, FAAP
Assistant Professor, Department of Surgery (Division of Plastic & Reconstructive Surgery); cross-appointed to Department of Microbiology & Immunology
IWK Health Centre; Dalhousie University Faculty of Medicine
Drug repurposing; interplay between wound healing, thrombosis, and tumour progression; adipose-derived stem cells and breast cancer; modulation of fibroblasts in desmoplastic reactions
Reconstruction following mastectomy is part of complete breast cancer care. Increasingly, a technique called autologous fat grafting is being used to restore soft tissue lost to cancer extirpation. Our group is exploring how adipose-derived stem cells in fat grafts may be used to impede tumour growth and improve reconstructive outcomes. Additionally, we are examining how agents used to reduce skin fibrosis may also be capable of modulating the desmoplastic reaction associated with malignant melanoma, thereby reducing the risk of metastasis.
Involvement with BHCRI to date:Dr. Michael Bezuhly is a Senior Scientist
Contact:IWK Health Centre, 5850/5980 University Avenue, PO Box 9700, Halifax, Nova Scotia, Canada, B3K 6R8
Murphy AM, Wong AL, Bezuhly M. Modulation of angiotensin II signaling in the prevention of fibrosis. Fibrogenesis Tissue Repair. 2015 Apr 23;8:7.
Phipps KD, Gebremeskel S, Gillis J, Hong P, Johnston B, Bezuhly M.
Alternatively activated M2 macrophages improve autologous Fat Graft survival in a mouse model through induction of angiogenesis. Plast Reconstr Surg. 2015 Jan;135(1):140-9.
Gupta R, Brace M, Taylor SM, Bezuhly M, Hong P. In search of the optimal processing technique for fat grafting. J Craniofac Surg. 2015 Jan;26(1):94-9.
Gillis JA, Gebremeskel S, Phipps K, Johnston P, Hong P, Bezuhly M.
N-Acetylcysteine (NAC) Improves Free Autologous Fat Graft Survival: A Preclinical Study. Plast Reconstr Surg. 2014 Oct;134(4 Suppl 1):70-1
Gebremeskel S, LeVatte T, Liwski RS, Johnston B, Bezuhly M. The reversible P2Y12 inhibitor ticagrelor inhibits metastasis and improves survival in mouse models of cancer. Int J Cancer. 2015 Jan 1;136(1):234-40.
Bezuhly M, Bucholtz J, Sigurdson L. Less scarring or more symmetry?
Reconstruction following metachronous bilateral breast cancer. J Plast Reconstr Aesthet Surg. 2012 Nov;65(11):1595-7.
Bezuhly M, Temple C, Sigurdson LJ, Davis RB, Flowerdew G, Cook EF Jr. Immediate postmastectomy reconstruction is associated with improved breast cancer-specific survival: evidence and new challenges from the Surveillance, Epidemiology, and End Results database. Cancer. 2009 Oct 15;115(20):4648-54.
Bezuhly M, Cullen R, Esmon CT, Morris SF, West KA, Johnston B, Liwski RS. Role of activated protein C and its receptor in inhibition of tumor metastasis. Blood. 2009 Apr 2;113(14):3371-4.