Dr. Luc J. Martin, PhD
Biology Department, Université de Moncton
Molecular endocrinology, Steroidogenesis, Transcriptional regulation, Cell-to-cell interactions, Tumor Leydig cells, Breast cancer
Xanthophylls in cancer prevention
Our research aims to study the carotenoids of xanthophylls type for their anti-proliferative and pro-apoptotic activities on cancer cells. We have shown that fucoxanthinol can reduce the viability of human breast cancer cell lines MCF-7 and MDA-MB-231 by modulation of NF-kappaB signaling pathway. Although uncommon, we are also interested to better understand the transcriptional regulatory mechanisms leading the development of testicular Leydig cell tumors.
Involvement with BHCRI to date:Dr. Luc Martin is an Associate Member
Contact:Université de Moncton, 18 avenue Antonine-Maillet, Moncton, New Brunswick, Canada, E1A 3E9
Martin,L.J. (2016) Cell interactions and genetic regulation that contribute to testicular Leydig cell development and differentiation. Molecular Reproduction and Development, 83, 470-87.
Roumaud,P. and Martin,L.J. (2015) Roles of leptin, adiponectin and resistin in the transcriptional regulation of steroidogenic genes contributing to decreased Leydig cells function in obesity. Hormone Molecular Biology and Clinical Investigation, 24, 25-45.
Martin,L.J. (2015) Fucoxanthin and its metabolite fucoxanthinol in cancer prevention and treatment, Marine Drugs, 13, 4784-98.
Daigle,M., Roumaud,P. and Martin,L.J. (2015) Expressions of Sox9, Sox5 and Sox13 transcription factors in mice testis during postnatal development. Molecular and Cellular Biochemistry, 407, 209-21.
Landry,D., Paré,A., Jean,S. and Martin,L.J. (2015) Adiponectin influences progesterone production from MA-10 Leydig cells in a dose-dependent manner. Endocrine, 48, 957-67.
Rwigemera,A., Mamelona,J. and Martin,L.J. (2015) Comparative effects between Fucoxanthinol and its precursor Fucoxanthin on viability and apoptosis of breast cancer cell lines MCF-7 and MDA-MB-231. Anticancer Research, 35, 207-219.
Mendoza-Villarroel,R.E., Robert, N.M., Martin,L.J., Brousseau,C. and Tremblay,J.J. (2014) The nuclear receptor Nr2f2 activates Star expression and steroidogenesis in mouse MA-10 and mLTC-1 Leydig cells. Biology of Reproduction, 91, 26-38.
Rwigemera,A., Mamelona,J. and Martin,L.J. (2014) Inhibitory effects of fucoxanthinol on the viability of human breast cancer cell lines MCF-7 and MDA-MB-231 are correlated with modulation of the NF-kappaB pathway. Cell Biology and Toxicology, 30, 157-167.
Daems,C., Martin,L.J., Brousseau,C. and Tremblay,J.J. (2014) Mef2 is restricted to the male gonad and regulates expression of the orphan nuclear receptor Nr4a1. Molecular Endocrinology, 28, 886-898.
Martin,L.J. (2014) Implications of adiponectin in linking metabolism to testicular function. Endocrine, 46, 16-28.