Dr. Karen Bedard, PhD
Associate Professor, Department of Pathology, Dalhousie University
Cross Appointment, Department of Pediatrics, Isaak Walton Killam Children’s Hospital
Affiliated Scientist, Division of Hematopathology, Nova Scotia Health Authority
Reactive Oxygen Species
Working as part of a collaborative team including clinicians, geneticists, and bioinformaticians, we are identifying mutations responsible for rare genetic disorders, including rare cancers. We use a combination of techniques including genotyping, genetic mapping, sequencing and Q-RT-PCR to identify the underlying genetic mutations. Our lab uses human cell culture models to study the impact of identified genetic variations on the function of particular genes, with a particular interest in the role of reactive oxygen species.
Involvement with BHCRI to date:Dr. Bedard is a BHCRI Senior Scientist
Contact:11th floor, Sir Charles Tupper Medical Building, Dalhousie University Faculty of Medicine, 5850 College Street, P.O. Box 15000, Halifax, Nova Scotia, Canada B3H 4R2
Obaid NM, Bedard K, Huang WY (2017) Strategies for Overcoming Resistance in Tumours Harbouring BRAF Mutations. International Journal of Molecular Sciences. (accepted, 2017)
Peer Reviewed Publications
Whitehouse S, Greensheilds A, Chen PL, Nightingale M, Hoskin D, Bedard K (2016) Resveratrol, piperine and apigenin differ in their NADPH-oxidase inhibitory and reactive oxygen species-scavenging properties. Phytomedicine 23: 1494-1503.
Bedard K, Whitehouse S, Jaquet V. (2015) Challenges, Progresses, and Promises for Developing Future NADPH Oxidase Therapeutics. Antioxid Redox Signal. 23:355-7.
Bentley V, Veinotte CJ, Corkery DP, Pinder J, Leblanc MA, Bedard K, Weng AP, Berman JN *, Dellaire G *. Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia Haematologica (2015) 100, 70-6 (IF 5.9)
Gaston D *, Hansford S *, Nightingale M, Macgillivray C, Kaurah P, Rideout A, Steele P, Huang WY, Whitehouse S, LeBlanc MA, Jiang H, Greer W, Samuels M, Orr A, Ludman M, Penney L, McMaster CR, Huntsman D, Bedard Kξ. Germline mutations in MAP3K6 are associated with familial diffuse gastric cancer (2014) PLoS Genetics e1004669 (ξ corresponding author, * authors contributed equally) (IF 8.5)
Robitaille JM; Gillett RM, LeBlanc MA, Gaston D, Nightingale MN, Mackley MP; Parkash K; Hathaway J, Thomas A, Ells A; Traboulsi EI, Héon E, Roy M, Shalev S, Fernandez CV, MacGillivray C, Wallace K, Fahiminiya S, Majewski J, McMaster CR, Bedard K. Phenotypic Overlap Between Familial Exudative Vitreoretinopathy (FEVR) and Microcephaly Lymphedema Chorioretinal Dysplasia (MLCRD) Caused by KIF11 Mutations (2014) 132; 1393-9. JAMAophthalmology (IF 3.8)
LeBlanc MA*, Penney LS*, Gaston D, Shi Y, Aberg E, Nightingale M, Jiang H, Gillett RM, Fahiminiya S, Macgillivray C, Wood EP, Acott PD, Khan MN, Samuels ME, Majewski J, Orr, McMaster CR, Bedard Kξ A rearrangement in OCLN causes brain calcification and renal dysfunction (2013) Human Genetics 132: 1222-34 (ξ corresponding author, * authors contributed equally) (IF 4.6)
Bogdanik L, Sleigh J, Tian C, Samuels ME, Bedard K, Seburn K, and Burgess RW Loss of Lrsam1, a Charcot-Marie-Tooth disease-associated E3 ubiquitin ligase, sensitizes peripheral axons to degeneration in mice (2013) Disease Models and Mechanisms 6: 780-92 (IF 5.0)
Copeland E, Renault N, Renault M, Dyack S, Bulman DE, Bedard K, Otley A, Magee F, Acott P and Greer WL. A Novel Splice-Site Mutation in ATP8B1 Results in Atypical Progressive Familial Intrahepatic Cholestasis Type 1 (2013) Journal of Gastroenterology and Hepatology 28:560-564 (IF 3.3)
Bedard K, Jaquet V (2012) Cell-free Screening for NOX Inhibitors Chem Biol 2012 19, 664-5 (IF 6.2)