Dr. Jules JE Doré, PhD
Associate Professor, Assistant Dean of Graduate Studies; Faculty of Medicine
Faculty of Medicine, Memorial University of Newfoundland
TGF-beta, signal transduction, cell cycle regulation
Transforming growth factor beta converts from a growth inhibitor to a promoter in cancer
During the transformation of normal cells to epithelial cancers the main hormone used to inhibit growth, TGF-beta, loses this ability. Worse, it becomes a stimulator of growth. My research is looking into how, inside a cancer cell, the signalling gets switched to make this happen. Recently we have zeroed in on the control of the activation of the Erk signalling pathway as one of the ways that prostate and ovarian cancers might be making the switch.