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  • Dr. Jules JE Doré, PhD

Appointments:

Associate Professor, Assistant Dean of Graduate Studies; Faculty of Medicine

Affiliations:

Faculty of Medicine, Memorial University of Newfoundland

Research Interests:

TGF-beta, signal transduction, cell cycle regulation

Transforming growth factor beta converts from a growth inhibitor to a promoter in cancer

During the transformation of normal cells to epithelial cancers the main hormone used to inhibit growth, TGF-beta, loses this ability. Worse, it becomes a stimulator of growth. My research is looking into how, inside a cancer cell, the signalling gets switched to make this happen. Recently we have zeroed in on the control of the activation of the Erk signalling pathway as one of the ways that prostate and ovarian cancers might be making the switch.

Involvement with BHCRI to date:

Dr. Doré is a BHCRI Senior Scientist and has been a member of a BHCRI Scientific Review Committee.

Phone:

(709) 777-8573

Contact:

Rm 5329, HSC, Memorial University of Newfoundland, St. John’s, NL, A1B 3V6
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