Dr. Jeanette Boudreau, PhD
Assistant Professor, Department of Microbiology and Immunology
Natural Killer cells, NK immunogenetics, cancer gene and expression profiling, bioinformatics
Precision natural killer cell therapy
Cancer results when mutations in a person’s DNA drive uncontrolled growth of a population of cells. Therefore, even with many common features, cancer is a unique disease in each patient. The Boudreau laboratory is defining the features of tumours that result from genetic mutations that can be targeted by a population of white blood cells called natural killers (NK), aiming to develop NK cells as precise effectors for immunotherapy.
Involvement with BHCRI to date:Dr. Jeanette Boudreau is a BHCRI Associate Member.
Phone:(902) 494 4536
Contact:Sir Charles Tupper Medical Building, Dalhousie University, 5850 College Street, P.O. Box 15000, Halifax, Nova Scotia, Canada B3H 4R2
Boudreau JE, Giglio F, Gooley TA, Stevenson PA, Le Luduec JB, Rajalinam R, Hou L, Katovich Hurley C, Lebedeva T, Noreen H, Reed EF, Yu N, Vierra-Green C, Haagenson MD, Malkki M, Petersdorf EW, Spellman S, Hsu KC. Donor KIR3DL1 and HLA-B subtype combinations predict acute myelogenous leukemia control after HLA9compatible hematopoietic cell transplantation. J Clin Oncol, 2017 Jul 10;35(20):2268-2278
Boudreau JE, Liu XR, Zhao Z, Zhang A, Schultz LD, Greiner DL, Dupont B, Hsu KC. Cell-extrinsic MHC class I molecule engagement augments human NK cell education programmed by cell-intrinsic MHC class I. Immunity, In Press.
Forlenza CJ, Boudreau JE, Zheng J, Heller G, Cheung NKV, Hsu KC. KIR3DL1 allelic polymorphism and affinity for HLA-Bw4 epitopes modulates response to anti-GD2 monoclonal antibody in patients with neuroblastoma. J Clin Oncol, ePub April 11, 2016.
Xiu F, Anipindi VC, Nguyen PV, Boudreau J, Liang H, Wan YH, Snider DP, Kaushic K. High physiological concentrations of progesterone reverse estradiol-mediated changes in differentiation and functions of bone marrow derived dendritic cells. PLOS ONE, 2016 Apr 11(4):e0153304.
Boudreau JE, Le Luduec JB, Mulrooney TJ, Hsu KC. Receptor and ligand density calibrate NK responsiveness: implications for HIV control. J Immunol, 2016 Mar 9 (ePub).
Boudreau JE, Wouters MC, Krawczyk CM. 8th Annual Canadian Cancer Immunotherapy Consortium (CCIC) Symposium 2015-May 20-22, Vancouver, Canada. Cancer Immunol Immunother. 2016 Feb;65(2):235-41
Mulrooney TJ, Zhang A, Goldgur Y, Boudreau JE, Hsu KC. KIR3DS1 specific D0 domain polymorphisms disrupt KIR3DL1surface expression and HLA binding. J Immunol. 2015 Aug 1;195(3):1242-50.
Karimi K, Karimi Y, Chan J, Boudreau JE, Bassett JD, Chew M, Reid S, Bramson JL, Wan YH, Ashkar AA. Type I IFN signaling on dendritic cells is required for NK cell-mediated anti-tumor immunity. Innate Immunity. Epub March 2015.
Boudreau JE, Le Luduec JB, Hsu KC. Development of a novel multiplex PCR assay to detect functional subtypes of KIR3DL1 alleles. PLOS ONE, 2014 Jun 11;9(6):e99543.
Zhang L, Bridle BW, Chen L, Pol J, Spaner D, Boudreau JE, Rosen A, Bassett JD, Lichty BD, Bramson JL Wan Y. Delivery of viral vectored vaccines by B cells represents a novel strategy to accelerate CD8+ T cell recall responses. Blood, 2013 Mar; 121(13): 2432-9. ePub 2013 Jan 16.