Dr. Francesca Di Cara, PhD
Department of Microbiology and Immunology
Department of Pediatrics
Peroxisomes, Innate immunity, Immunometabolism, Lipid signaling, Stem cells proliferation, Intestinal epithelium integrity and Homeostasis, host-pathogens/commensals interaction
Cancer cells often alter metabolism to support their malignant phenotype. My group studies peroxisomes, ubiquitous membrane-bounded organelles that play a central role in regulating various metabolic activities, such as the turnover of complex lipids and reactive oxygen species, as immunometabolic organelle. Emerging evidence shows peroxisomes function as pivotal signalling platforms that modulate a growing number of conserved oncogenic or tumour suppressor pathways. My group rely on the genetic of Drosophila melanogaster to determine the cellular networks that regulate peroxisome activity in cancer cells and identify the peroxisomal contributions to cancer-specific metabolic alterations important to drive malignancy.