Dr. Etienne Hébert Chatelain, PhD
Assistant Professor, Biology, Department of Biology, Université de Moncton
Université de Moncton
Mitochondria, cellular signaling, Phosphoproteome, Src kinase, Breast cancer
Targeting the mitochondrial phosphoproteome in cancer
Phosphorylation of mitochondrial proteins emerged as a powerful regulation pathway of cellular homeostasis. My team aims to understand the importance of these processes in the development of different pathologies including breast cancer. Notably, we focus on intra-mitochondrial Src kinase which is hyperactivated in several types of cancer. The characterization of the mitochondrial phosphoproteome in different models of cancer will allow my team to establish these events as therapeutic targets for breast cancer.