Dr. Denis J. Dupré, PhD
Professor, Department of Pharmacology
G protein coupled receptors, cannabinoids, Cannabis, terpenes, plant derived drugs, signal transduction, chemotherapy resistance, breast cancer
Understanding how cannabinoids and their receptors regulate cancer progression and metastasis in various models
In my lab, we study how G protein coupled receptors, like cannabinoid or bitter taste receptors are involved in normal functions or disease states. Signaling from GPCRs is involved in many different therapies and our goal is to understand the effect of different drugs, like cannabinoids present in Cannabis, on various signaling pathways involved in cancer. We try to understand how different ligands induce different responses, and how this will influence disease progression. One of our goals is to identify new targets to help in cancer therapy including cancers that are resistant to chemotherapy.
Hometown: Sherbrooke, Qc
What brought you to your current institution?
After postdoc, I got my first interview at Dalhousie University during my first visit in the Maritimes. Halifax seemed like a great place to work and raise my family and I’ve been here since then.
Learn more about my research: https://medicine.dal.ca/departments/department-sites/pharmacology/our-people/faculty/denis-dupre.html
Involvement with BHCRI to date:I am a BHCRI Senior Scientist, participated in the supervision of CRTP students, invited speaker for the seminar series, participated in grant and scholarship review for BHCRI
Contact:Sir Charles Tupper Medical Building, Dalhousie University, 5850 College Street, P.O. Box 15000, Halifax, Nova Scotia, Canada B3H 4R2
Gillies K, Wertman J, Charette N, Dupré DJ. Anterograde Trafficking of CXCR4 and CCR2 Receptors in a Prostate Cancer Cell Line. Cell Physiol Biochem. 2013
Langelaan DN, Reddy T, Banks AW, Dellaire G, Dupré DJ, Rainey JK. Structural features of the apelin receptor N-terminal tail and first transmembrane
segment implicated in ligand binding and receptor trafficking. BBA – Biomembranes 2013 Feb 22;1828(6):1471-1483
Wertman J, Dupré DJ, G protein-coupled receptor dimers: Look like their parents, but act like teenagers! J Recept Signal Transduct Res. 2013 Jun;33
Dupré DJ, Hammad MM, Holland P, Wertman J, Role of chaperones in G protein coupled receptor signaling complex assembly, GPCR Signalling Complexes –
Synthesis, Assembly, Trafficking and Specificity, Springer Subcellular Biochemistry Series 63, chapter 2, 23-42
Dupré DJ, Rola-Pleszczynski M, Stankova J, Rescue of internalization-defective platelet-activating factor receptor function by EBP50/NHERF1. J Cell Commun
Signal. 2012 Dec;6(4):205-16
Kuang YQ, Charette N, Frazer J, Holland PJ, Attwood KM, Dellaire G, Dupré DJ, Dopamine receptor interacting protein 78 acts as a molecular chaperone for
chemokine receptors signaling complex organization. PLoS ONE 2012 7(7): e40522
Hammad MM, Kuang YQ, Morse A, Dupré DJ, Rab1 interacts directly with beta2-adrenergic receptor to regulate receptor anterograde trafficking. Biological
Chemistry, 2012 May 1;393(6):541-6
Deyts C, Vetrivel KS, Shepherd YM, Dupré DJ, Thinakaran G, Parent AT: Novel GalphaS-protein signaling associated with membrane-tethered APP intracellular
domain. Journal of Neuroscience 2012 Feb1 32(5) 1714-1729
Kuang YQ, Pang W, Zheng YT, Dupré DJ: NHERF1 regulates gp120-induced internalization and signaling by CCR5, and HIV-1 production. European Journal of
Immunology, 2012 Feb;42(2):299-310
Charette N, Holland P, Frazer J, Allen H, Dupré DJ: Dependence on Different Rab GTPases for the Trafficking of CXCR4 and CCR5 Homo or Heterodimers Between
the Endoplasmic Reticulum and Plasma Membrane in Jurkat Cells. Cellular Signalling (2011) 23, 1738–1749.