Dr. Denis J. Dupré, PhD
Associate Professor, Department of Pharmacology
Faculty of Medicine, Dalhousie University
G protein coupled receptors, chemokines, signal transduction, protein-protein interaction, signaling complex assembly, trafficking and chaperones involved in assembly
Understanding how chemokine receptors contribute to cancer development and metastasis
90% of cancer mortality is associated with the spread of tumor cells. Several cellular factors have been shown to be important for metastasis, including proteins at the surface of tumor cells like CXCR4. In the Dupré lab, we identify and characterize proteins that change the way CXCR4 produces signals, with the goal of identifying new anti-metastasis drug targets.