Dr. Christopher D. Richardson, PhD
Departments of Microbiology & Immunology/Pediatrics, Canadian Centre for Vaccinology (IWK Health Centre), Canada Research Chair (Tier I) in Vaccinology and Viral Therapeutics, Co-Principal Investigator for the Canadian Network for Hepatitis C (CanHepC)
Oncolytic viral immune therapy, adenocarcinomas, breast cancer, bladder cancer, liver cancer, nectin-4 tumour marker
Our laboratory recently discovered a “receptor” for measles virus which turned out to be a tumor marker called PVRL4/Nectin-4. This marker is found on many breast, bladder, and liver tumours. Receptors are cellular molecules to which the virus attaches, in order to initiate infection. This explains why measles virus can target a wide variety of cancers. We are using a mouse breast cancer model to investigate whether measles and an engineered hybrid virus can kill tumors.
Involvement with BHCRI to date:Dr. Christopher Richardson is a Senior Scientist
Contact:Canadian Centre for Vaccinology, IWK Health Centre, Goldbloom Pavilion, Laboratory 1 East, 5850/5980 University Ave., Halifax NS, B3K 6R8
Noyce R.S., Bondre D., Ha M., Sisson G., Lin L.-T., Tsao M.-S., and Richardson C.D. (2011) Tumor Cell Marker PVRL4 (Nectin 4) Is an Epithelial Cell Receptor for Measles Virus. PLoS Pathogens 7(8): e1002240. Cover picture for August PLoS Pathogens web page and subject of PLoS Pathogens press release. Article reviewed by Science Dec. 23 issue and featured on TWIV Jan. 2012.
Noyce R.S. and Richardson C.D. (2012) Nectin 4 is the Epithelial Cell Receptor for Measles Virus. Trends Microbiol. 20(9), 429-39.
Noyce R.S., Delpeut S., and Richardson C.D. (2013) PVRL4/Nectin-4 is the epithelial cell receptor for canine distemper virus. Virology 436, 210-220.
Lin L.-T., Chen T.-Y. Lin S.-C, Chung C.-Y., Lin T.C., Wang G.-H., Anderson R., Lin C.-C., and Richardson C.D. (2013). Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses that use glycosaminoglycans for entry. BMC Microbiol 13, 187-202.
Delpeut S., Noyce R.S, and Richardson C.D. (2014). The V domain of dog PVRL4 (nectin-4) mediates canine distemper virus entry and virus cell-to-cell spread . Virology 454, 109-117.
Lin L-T., and Richardson (2016). The host cell receptors of measles virus and their interaction with the viral hemagglutinin (H) protein. Viruses 8(9) pii: E250.
Delpeut S., Sisson G., Black K.M., and Richardson C.D. (2017). Measles virus enters breast and colon cancer cells through a PVRL4-mediated macropinocytosis pathway. J. Virology, 91(10). pii: e02191-16.
Ha M. N., Delpeut S., Noyce R.S., Lin L.-T., Plemper R., and Richardson C.D. (2017). Mutations in the fusion protein of measles virus that confer resistance to the membrane fusion inhibitors carbobenzoxy-D-Phe-L-Phe-Gly and AS-48. J. Virology 91(23). pii: e01026-17.
van Buuren N., Tellinghuisen T.L., Richardson C.D., and Kirkegaard K. (2018). Transmission genetics of drug-resistant hepatitis C virus. Elife 7: e32579 [Epub ahead of print].