Dr. Andrew Stadnyk, PhD
Research Investigator, Maritime Intestinal Research Alliance - pediatrics, http://mirapeds.ca/
Professor, Division of Gastroenterology & Nutrition, Department of Pediatrics and Department of Microbiology & Immunology, Faculty of Medicine, Dalhousie University; Scientific Staff, IWK Health Centre
Mucosal inflammation, digestive system diseases, oral and intestinal mucositis, colon cancer, inflammatory bowel diseases, complement system
Unremitting inflammation is the leading risk factor for colon cancer. Accordingly, we have applied our discoveries related to inflammatory processes in the intestines to identify how inflammation contributes to the emergence of cancers (publication 1). Recently this included dissecting the inflammatory processes triggered by chemotherapeutic drugs (mucositis), in particular, the role of molecules from the complement system. We are the first to report that complement becomes activated during model mucositis in mice. (publication 2). Chronic complement activation also happens to favor cancer cell growth, so we are exploring how interrupting complement activation may mitigate mucositis while reducing cancer cell growth.