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  • Dr. Andrew P. Makrigiannis, Ph.D.

Appointments:

Professor and Head, Department of Microbiology and Immunology

Affiliations:

Dalhousie University

Research Interests:

Natural Killer (NK) cell and NK cell receptor genetics and function in cancer immunosurveillance and pathogen recognition.

Dr. Makrigiannis studies the role of class I major histocompatiblity complex (MHC-I) receptors (Ly49) on NK cells during anti-cancer responses. Mouse Ly49 receptors are the functional counterpart of human KIR receptors. He has discovered that cancer cells modulate their surface MHC-I levels to evade recognition by NK cells. He seeks to understand the mechanism of MHC-I modulation in cancer cells, and devise counteractive measures to make cancer cells more susceptible to NK cell-mediated killing.

Involvement with BHCRI to date:

Dr. Makrigiannis is a BHCRI Senior Scientist.

Phone:

(902) 494-2736

Contact:

Sir Charles Tupper Medical Building, Dalhousie University, 5850 College Street, P.O. Box 15000, Halifax, Nova Scotia, Canada B3H 4R2
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