The Beatrice Hunter Cancer Research Institute logo
  • Dr. Amitabh Jha, MSc, PhD

Appointments:

Professor, Department of Chemistry, Acadia University
George H. Wallace Chair of Chemistry, Acadia University
Adjunct Professor, Department of Biology, Acadia University

Affiliations:

Acadia University

Research Interests:

Drug Design, Medicinal Chemistry, Anticancer Drug Development, Synthetic Organic Chemistry, Green Chemistry

Anticancer Medicinal Chemistry

Research efforts in Dr Jha’s laboratory have led to identification of several clusters of novel anti-tumor agents (human topoisomerase 2 inhibitors and selective estrogen receptor modulators). The topoisomerase-2 inhibitors under investigation are structurally divergent from known inhibitors and therefore may be of value in developing treatment for drug-resistant tumors. The in-vitro IC50 values of some of Dr Jha’s compounds against an array of cancer cell lines were found to be in the nanomolar range. His group has also established that these compounds display selective cytotoxicity towards tumor cells and are not general biocidal agents. In addition, a number of these compounds were found to be unaccompanied by murine toxicity in in-vivo models for dose up to 300 mg/kg.

Involvement with BHCRI to date:

Dr. Jha is a BHCRI Senior Scientist

Phone:

(902) 585-1515

Contact:

108 Elliott Hall, 6 University Avenue, Acadia University, Wolfville, Nova Scotia, Canada, B4P 2R6
Site by: Spectacle Group