Dr. Kensuke Hirasawa, PhD
Associate Professor, Memorial University, St. John's
Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland
Interferon, cellular signaling pathways, Ras/MEK, transcriptional regulators
Interferons (IFNs), which are produced inducibly by most cells in the body, have been used with clinical success in the treatment of several different types of cancers. However, the presence of cancer cells resistant to IFNs often reduces the treatment efficacy. We study aspects of the cancer cellular environment that reduce IFN’s efficacy to activate the antitumor machinery. Our research should provide a novel insight into the future development of effective IFN treatment to fight against cancer.