Dr. Jan Rainey, PhD
Assistant Professor, Department of Biochemistry & Molecular Biology, cross-appointed to Department of Chemistry
Dalhousie University Faculty of Medicine, Dalhousie University Faculty of Science
Structural biology; Regulatory peptides; Membrane proteins; Extracellular matrix; G-protein coupled receptor activation mechanisms; Therapeutic design; Nuclear magnetic resonance (NMR) spectroscopy; Atomic force microcsopy; Fluorescence & circular dichroism spectroscopy.
Using structural biology to combat cancer
My laboratory studies the progression of cancer at the atomic level. The major current focus of our research on the cancer front is the hormone apelin and its cell-surface receptor protein, which can be hijacked by a tumour to allow formation of new blood vessels to feed its growth. By revealing the shapes and chemical properties of apelin and its receptor protein, we aim to design drugs to prevent the usage of this system for tumour growth.