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  • Brett Duguay, PhD

Supervisor:

Dr. Craig McCormick

Program of Study:

Postdoctoral Fellow, Microbiology & Immunology

Project Title:

Elucidating mechanisms of translational control by Kaposi’s sarcoma-associated herpesvirus

Scholarships and/or Awards:

  • 2018-2020: Cancer Research Training Program (CRTP) Traineeship
  • 2009-2014: Alberta Innovates – Health Solutions, Full-time Studentship
  • 2009: Government of the Province of Alberta, Queen Elizabeth II Graduate Scholarship-Doctoral Level

Career Aspirations:

I am interested in understanding how human viruses modify the cellular environment during infection and the broad impact of these changes for the host. Following my postdoctoral training, I hope to continue in academic research with a focus on better understanding host-pathogen interactions and the development of new therapeutics for viral diseases.

Location:

Dalhousie University

Publications:

Monjo, A.L., Pringle, E.S., Thornbury, M., Duguay, B.A., Monro, S.M.A., Hetu, M., Knight, D., Cameron, C.G., McFarland, S.A. and C. McCormick. 2018. Photodynamic Inactivation of Herpes Simplex Viruses. Viruses. 10(10): E532.

Duguay, B.A., Huang, K.W. and M. Kulka. 2018. Lipofection of plasmid DNA into human mast cell lines using lipid nanoparticles generated by microfluidic mixing. J Leukoc Biol. 104(3):587-96. 

Dauber, B., Poon, D., Dos Santos, T., Duguay, B.A., Mehta, N., Saffran, H.A. and J.R. Smiley. 2016. The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation. J Virol. 90(13):6049-57. 

West, A.P., Khoury-Hanold, W., Staron, M., Tal, M.C., Pineda, C.M., Lang, S.M., Bestwick, M., Duguay, B.A., Raimundo, N., MacDuff, D.A., Kaech, S.M., Smiley, J.R., Means, R.E., Iwasaki, A. and G.S. Shadel. 2015. Mitochondrial DNA stress primes the antiviral innate immune response. Nature. 520(7548):553-7. 

Duguay, B.A., Saffran, H.A., Ponomarev, A., Duley, S.A., Eaton, H.E. and J.R. Smiley. 2014. Elimination of mitochondrial DNA is not required for herpes simplex virus 1 replication. J Virol. 88(5):2967-76.

Duguay, B.A. and J.R. Smiley JR. 2013. Mitochondrial nucleases ENDOG and EXOG participate in mitochondrial DNA depletion initiated by herpes simplex virus 1 UL12.5. J Virol. 87(21):11787-97.

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