Brett Duguay, PhD
Supervisor:Dr. Craig McCormick
Program of Study:Postdoctoral Fellow, Microbiology & Immunology
Project Title:Elucidating mechanisms of translational control by Kaposi’s sarcoma-associated herpesvirus
Scholarships and/or Awards:
- 2018: Cancer Research Training Program (CRTP) Traineeship
- 2009-2014: Alberta Innovates – Health Solutions, Full-time Studentship
- 2010: 35th Annual International Herpesvirus Workshop, Phase III Travel Award
- 2009: Government of the Province of Alberta, Queen Elizabeth II Graduate Scholarship-Doctoral Level
I am interested in understanding how human viruses modify the cellular environment during infection and the broad impact of these changes for the host. Building on my PhD training in virology, I plan to apply my experience to the study of host-pathogen interactions and viral oncogenesis mediated by Kaposi’s sarcoma-associated herpesvirus. My goal is use this postdoctoral position to develop an independent research program which will serve as the foundation for my career as an academic researcher.
Monjo, A.L., Pringle, E.S., Thornbury, M., Duguay, B.A., Monro, S.M.A., Hetu, M., Knight, D., Cameron, C.G., McFarland, S.A. and C. McCormick. 2018. Photodynamic Inactivation of Herpes Simplex Viruses. Viruses. 10(10): E532.
Duguay, B.A., Huang, K.W. and M. Kulka. 2018. Lipofection of plasmid DNA into human mast cell lines using lipid nanoparticles generated by microfluidic mixing. J Leukoc Biol. 104(3):587-96.
Dauber, B., Poon, D., Dos Santos, T., Duguay, B.A., Mehta, N., Saffran, H.A. and J.R. Smiley. 2016. The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation. J Virol. 90(13):6049-57.
West, A.P., Khoury-Hanold, W., Staron, M., Tal, M.C., Pineda, C.M., Lang, S.M., Bestwick, M., Duguay, B.A., Raimundo, N., MacDuff, D.A., Kaech, S.M., Smiley, J.R., Means, R.E., Iwasaki, A. and G.S. Shadel. 2015. Mitochondrial DNA stress primes the antiviral innate immune response. Nature. 520(7548):553-7.
Duguay, B.A., Saffran, H.A., Ponomarev, A., Duley, S.A., Eaton, H.E. and J.R. Smiley. 2014. Elimination of mitochondrial DNA is not required for herpes simplex virus 1 replication. J Virol. 88(5):2967-76.
Duguay, B.A. and J.R. Smiley JR. 2013. Mitochondrial nucleases ENDOG and EXOG participate in mitochondrial DNA depletion initiated by herpes simplex virus 1 UL12.5. J Virol. 87(21):11787-97.