Wasundara Fernando, BSc (Pharmacy), MSc
Supervisor:Dr. David Hoskin
Co-supervisor:Dr. Vasantha Rupasinghe
Program of Study:PhD
Project Title:Antimetastatic activity and pharmacokinetics of docosahexaenoic acid acylated phloridzin (PZ-DHA): Targeting breast cancer
Scholarships and/or Awards:
- Cancer Research Training Program (CRTP) Traineeship Award 2017
- Cancer Research Training Program (CRTP) Traineeship Award 2015
- TFRI Travel Award 2015
- Cancer Research Training Program (CRTP) Traineeship Award 2014
- CRTP Travel Award 2014
- First place in oral presentations of Graduate Research Day 2014: Faculty of Agricuture, Dalhousie University, 2014
- CIFST Travel grant, 2014
- Truro Rotary Club scholarship, 2012
- Astron Scholarship for Pharmacy, 2008
Wasu’s research interest is continued in the field of Natural Product Chemistry and investigation of pharmacological activities of phytochemicals and their derivatives. She obtained her B.Sc. degree in Pharmacy from the University of Colombo and M.Sc. from Dalhousie University. Wasu is pursuing her Ph.D. studies at the Department of Pathology, Dalhousie University and her research explores the efficacy and safety of phloridzin docosahexaenoate (a novel fatty acid ester derivative of flavonoid) to treat metastatic breast cancer. Upon completion of her Ph.D., Wasu is hoping to continue her research further in the field of breast cancer research.
Fernando, W., Coombs, M. R. P., Hoskin, D. W. and Rupasinghe, H. P. V. (2016). Docosahexaenoic acid-acylated phloridzin, a novel polyphenol fatty acid ester derivative, is cytotoxic to breast cancer cells. Carcinogenesis, 37(10), 1004–1013.
Fernando, W., Rupasinghe, H. P. V. and Hoskin, D. W. (2015). Regulation of Hypoxia-inducible Factor-1a and Vascular Endothelial Growth Factor Signaling by Plant Flavonoids. Mini-Rev. Med. Chem., 15, 479-489.
Fernando, W. and Rupasinghe, H. P. V. (2013). Anticancer properties of phytochemicals present in medicinal plants of North America. In: Using Old Solutions to New Problems - Natural Drug Discovery in the 21st Century. (Ed.) Marianna Kulka. InTech - Open Access Publisher. Rijeka, Croatia. ISBN: 978-953-51-1158-0. pp. 159-180.
Fernando, T. R. G. W., Ratnasooriya, W. D., Deraniyagala, S. A. Antinociceptive activity of aqueous leaf extract of Tetracera sarmentosa L. in rats. (2009). Phcog Res. 1(6): 381-386.