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  • Simon Gebremeskel, BScH

Supervisor:

Dr. Brent Johnston

Program of Study:

PhD Candidate, Microbiology and Immunology

Project Title:

Examining the role of NKT cell in anti-tumor immunity

Scholarships and/or Awards:

  • CIHR doctoral Award (2015) 
  • Best Poster Presentation- TFRI annual scientific meeting (2015)
  • Izaak Walton Killam Predoctoral Scholarship (Level 2, 2013-2015) 
  • The Presidents award (2013-2015)
  • Best Poster Presentation- TFRI annual scientific meeting (2013) 
  • CIHR-ICR/TFRI Travel award (2013) 
  • Best Oral Presentation- Pediatrics Research day (2013)
  • NSERC postgraduate scholarship-Alexander Graham Bell Canada Graduate      Scholarship (CGS) 2012-2013
  • Cancer Research Training Program (CRTP) Traineeship Award  2012-2014
  • Nova Scotia Health Research Foundation Scholarship 2012-2013
  • Most dynamic oral presentation- Microbiology and Immunology symposium 2012
  • Best Oral presentation-Pediatrics research day 2012
  • St Michaels Hospital summer research scholarship 2011
  • Institute of Medical Sciences Scholarship 2011 (Declined)
  • St Michaels Hospital poster award 2011
  • BSCH- distinction awarded 2011
  • NSERC undergraduate research award 2010
  • Queen Elizabeth aiming for the top scholarship (2010-2011)
  • Queen Elizabeth aiming for the top scholarship (2009-2010)
  • Queen Elizabeth aiming for the top scholarship (2008-2009)
  • Queen Elizabeth aiming for the top scholarship (2007-2008)
  • Queen’s university excellence scholarship (2007)
  • Millennium scholarship (2007)
  • Ontario Scholar award (2007)

Career Aspirations:

In the future, Simon will pursue a PhD/MD degree with a particular focus in the field of Immuno-Oncology. He plans to use his undergraduate background in drug discovery, graduate background in immunology and future medical training in oncology, to streamline the entry of novel immunotherapies to the clinic.

Location:

Dalhousie University

Publications:

Gillis J*, Gebremeskel S*, Phipps K, Johnston B, Hong P, Bezuhly M. Effect of N-Acetylcysteine on Adipose-derived Stem Cell and Autologous Fat Graft Survival in a Mouse Model. Plastic and reconstructive surgery. 136(2):179e-88e. doi: 10.1097/ PRS.0000000000001443. * Co-first author.

Gebremeskel S, Slauenwhite D, Johnston B. 2015. Reconstitution models to evaluate natural killer T cell function in tumor control. Immunology and Cell biology. [Epub ahead of print]. doi: 10.1038/icb.2015.67. 

Gebremeskel S, Clattenburg DR, Slauenwhite D, Lobert L,  Johnston B. 2015. Post-Surgical NKT cell based immunotherapy to target metastatic breast cancer. Oncoimmunology. 4:3 e995562. doi: 10.1080/2162402X.2014.995562.

Phipps KD*, Gebremeskel S*, Gillis J, Hong P, Johnston B, Bezuhly M. 2015. Alternatively activated macrophages improve autologous fat graft survival in a mouse model via induction of angiogenesis. Plastics and reconstructive surgery.135(1):140-9. doi: 10.1097/PRS.00000-00000000793. *Co-first author.

Gebremeskel S, Levatte T, Liwski RS, Johnston B, Bezuhly M. 2015. The reversible P2Y12 inhibitor ticagrelor inhibits metastasis and improves survival in mouse models of cancer. International Journal of Cancer. 234–240. doi: 10.1002/ijc.28947.

Slauenwhite DO, Gebremeskel S, Doucette CD, Hoskin DW, Johnston B. 2014. The chemokine receptor CXCR6 regulates cytokine polarization and T cell recruitment to inflamed paws in collagen-induced arthritis. Arthritis and Rheumatism. 66:3001-12. doi: 10.1002/art.38816.

Qiu W, Lam R, Voytyuk O, Romanov V, Gordon R, Gebremeskel S, Vodsedalek J, Thompson C, Beletskaya I, Battaile KP, Pai EF, Rottapel R, Chirgadze NY. Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2. Acta Crystallogr Sect D Biol Crystallogr 2014, 70:1–14. doi: 10.1107/S1399004714017660.

Aslam R, Hu Y, Gebremeskel S, Segel GB, Speck ER, Guo L, Kim M, Ni H, Freedman J, Semple JW. (2012). Thymice retention of T regulatory cells is associated with peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia. Blood 120(10):2127-32. doi: 10.1182/blood-2012-02-413526.

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