Patrick Murphy, MSc, PhD
Supervisor:Dr. Shashi Gujar
Program of Study:Postdoctoral Fellow, Microbiology and Immunology
Project Title:Exploiting reovirus-induced antigen presentation to enhance cancer immunotherapy
Scholarships and/or Awards:
- Canadian Cancer Society Research Institute Innovation Grant (co-author) (2015)
- Cancer Research Training Program (CRTP) Traineeship Award 2015
- Natural Sciences and Engineering Research Council Industrial Post-Graduate Scholarship (2007)
- NSAC Graduate Entrance Scholarship (2005)
A significant portion of cancer research in the past 10-15 years has been burgeoned by technological advances in mass spectrometry. Patrick envisions that advances in mass spectrometry will to continue to answer many of the open questions in cancer biology, such as how cancer cells metabolize nutrients differently than normal cells and how they evade immune responses. He has gained expertise in studying cancer cells using mass spectrometry while at Steve Gygi’s laboratory at Harvard. Patrick is particularly intrigued by the potential for mass spectrometry to understand metabolic and immune aspects of cancer and will continue to develop this area of research in the pursuit of eventually starting his own laboratory.
Coloff JL, Murphy JP, Braun CR, Harris IS, Shelton LM, Kami K, Gygi SP, Selfors LM, Brugge JS. Differential glutamate metabolism in proliferating and quiescent mammary epithelial cells. Cell Metab. 2016 (accepted).
Sharif T, Ahn D-G, Liu R-Z, Pringle E, Martell E, Dai C, Nunokawa A, Kwak M, Clements D, Murphy JP, Dean C, Marcato P, McCormick C, Godbout R, Gujar SA, Lee PWK. The NAD+ salvage pathway modulates cancer cell viability via p73. Cell Death Differ, 2016, 23:669-680
Jastrab JB. Wang T, Murphy JP, Bai L, Hu K, Merkx R, Huang J, Chaterjee C, Ovaa H, Gygi SP, Li H, Darwin KH. An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA. 2015, 112:E1763-E1722
Murphy JP, Stepanova E, Everley RA, Paulo, JA, Gygi SP. Comprehensive temporal protein dynamics during the diauxic shift in Saccharomyces cerevisea. Mol. Cell Proteomics. 2015, 14:2454-2465
Liew GM, Ye F, Nager AR, Murphy JP, Lee JS, Aguiar M, Breslow DK, Gygi SP, Nachury MV. The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3. Dev. Cell. 2014, 31, 265-278
Murphy JP, Everley RA, Coloff JL, Gygi SP. Combining amine metabolomics and quantitative proteomics of cancer cells using derivatization with isobaric tags. Anal. Chem. 2014, 86, 3585-3593
Yamada T, Yang Y, Hemberg M, Yoshida T, Cho HY, Murphy JP, Fioravante D, Regehr WG, Gygi SP, Georgopoulos K, Bonni A. Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain. Neuron. 2014, 83, 122-134
Murphy JP, Côté PD, Pinto DM. Monitoring the switch: The Warburg effect and targeted proteomic analysis of cancer metabolism. Current Proteomics, 2012, 9, 26-39.
Murphy JP, Pinto DM. Targeted proteomic analysis of glycolysis in cancer cells. J. Proteome Res., 2011, 10(2), 604-613.
Murphy JP, Pinto DM. Temporal proteomic analysis of IGF-1R signalling in MCF-7 breast adenocarcinoma cells. Proteomics, 2010, 10(9), 1847-1860.