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  • Marie-Laurence Tremblay, PhD

Supervisor:

Dr. Kimberly Brewer

Program of Study:

Postdoctoral Fellow

Project Title:

Tracking and Quantitation of Immune Cell Populations in Response to Cancer Immunotherapy by MRI: A Pre-Clinical Tool for Monitoring Treatment Outcome

Scholarships and/or Awards:

Scholarships:

  • Cancer Research Training Program (CRTP) Traineeship Award 2016
  • Apr 2016 BHCRI-Cancer Research Training Program for Post-Doctoral Fellow, $36,750 for 2 years
  • May 2012-15 Natural Sciences and Engineering Research Council (NSERC) PGS-D, PhD level, $64,000 over 3 years
  • May 2012-14 Nova Scotia Health Research Foundation (NSHRF) award, PhD level, $20,000 over 2 years (Declined)
  • May 2012-13 Dalhousie University President’s Award, $8000
  • Oct 2010 NSHRF REDI for research skills, $2000
  • Sept 2010-11 NSHRF, Master’s level, $16,824 over 1 year

Awards:

  • April 2017 Woman in Cancer Research AACR travel award, $2000 USD
  • March 2014 Experimental NMR Conference student travel stipend, $300
  • May 2013 Industrial Chemistry Award, 96th Canadian Society for Chemistry meeting, $150
  • Oct 2012 Student Presentation Award, MOOT XXV meeting, $150
  • Aug 2012 PhD travel award, Dalhousie Faculty of Graduate Studies, $400
  • Oct 2011 Poster award, MOOT XXIV meeting, $75
  • Oct 2010 Poster award, MOOT XXIII meeting, $75

Career Aspirations:

I am a biophysicist with prior training in protein structure using nuclear magnetic resonance. I am now expanding my training into pre-clinical molecular imaging using MRI at the Biomedical Translational Imaging Center in Halifax. I am currently investigating the quantitative migratory patterns of immune cells in response to different immunotherapies with the goal of developing pre-clinical biomarkers of therapy success. I hope to stay in the field of biophysics, particularly in imaging, to develop pre-clinical methods that will ensure higher cancer therapy success rates for clinical trials.  I hope to eventually find work in industry or as an academic.

Location:

IWK Health Centre

Publications:

Tremblay M-L, Xu L, Sarker M, Liu X-Q, Rainey JK (2016) Characterizing Aciniform Silk Repetitive Domain Backbone Dynamics and Hydrodynamic Modularity. International Journal of Molecular Sciences 17:1305

Sarker M, Orrell KE, Xu L, Tremblay M-L, Bak, JJ, Liu, XQ, Rainey, JK (2016) Tracking Transitions in Spider Wrapping Silk Conformation and Dynamics by 19F Nuclear Magnetic Resonance Spectroscopy. Biochemistry 55:3048–3059

Tremblay M-L, Xu L, Sarker M, Lefèvre T, Leclerc J, Pézolet M, Auger M, Meng Q, Liu XQ, Rainey JK (2015).  Spider wrapping silk fibre architecture arising from its modular soluble protein precursor.  Scientific Reports, 26:5, 11502

Eftaiha AF, Tremblay M-L, Rainey JK, Paige MF (2015). The effect of perfluorooctadecanoic acid on a model phosphatidyl choline-peptide pulmonary lung surfactant mixture.  Journal of Fluorine Chemistry 177:55-61

Xu L, Tremblay M-L, Orrell KE, Leclerc J, Meng Q, Liu XQ, Rainey JK (2013) Nanoparticle self-assembly by a highly stable recombinant spider wrapping silk protein subunit. FEBS Letters 587:3273-3280

Kehoe S, Tremblay M-L, Coughlan A, Towler MR, Rainey JK, Abraham RJ, Boyd D (2013) Preliminary Investigation of the Dissolution Behavior, Cytocompatibility, Effects of Fibrinogen Conformation and Platelet Adhesion for Radiopaque Embolic Particles. Journal of Functional Biomaterials 4(3):89-113

Tremblay M-L, Xu L, Meng Q, Liu XQ, Rainey JK (2012) 1H, 13C and 15N NMR assignments of the aciniform spidroin (AcSp1) repetitive domain of Argiope trifasciata wrapping silk.  Biomolecular NMR assignments 6:147-151

Tremblay, M-L, Banks AW, Rainey JK (2010) The predictive accuracy of chemical shifts is more affected by protein secondary structure than solvent environment. Journal of Biomolecular NMR 46:257-270

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