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  • Krysta Coyle, BSc

Supervisor:

Dr. Paola Marcato

Program of Study:

PhD, Pathology

Project Title:

Improving the efficacy of retinoic-acid-based therapies in triple-negative breast cancer

Scholarships and/or Awards:

  • CIHR Doctoral Research Award, 2015-2018
  • NSHRF Scotia Scholars (PhD) Award, 2015-2017
  • Killam Predoctoral Scholarship (level 2), 2015-2016
  • Dalhousie President’s Award, 2015-2016
  • AACR Scholar-in-Training Award, 2015
  • Top graduate student poster presentation, Pathology Research Day, 2015
  • Dr Bernard Badley Music-in-Medicine Scholarship, 2015
  • Cancer Research Training Program (CRTP) Traineeship Award, 2014-2015
  • Top MSc student oral presentation, IHRTP Research Day, 2014
  • Top graduate student oral presentation, Pathology Research Day, 2014

Career Aspirations:

Krysta developed a love for research during her undergraduate co-op degree at UBC. Her graduate training is reinforcing her passion for science as it is challenging, exciting, and encouraging. Ultimately, Krysta sees a future for herself in academic cancer research. After completing her PhD, she plans to pursue post-doctoral training in a challenging, high-intensity cancer research lab.

Location:

Dalhousie University

Publications:

Coyle KM, Thomas ML, Sultan M, Marcato P. Chapter 15: Targeting Key Stemness-Related Pathways in Human Cancers. In Babashah S. Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology. Springer. In press.

Thomas ML, Coyle KM, Sultan M, Marcato P. Chapter 17: Cancer Stem Cells and Chemoresistance: Strategies to Overcome Therapeutic Resistance. In Babashah S. Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology. Springer. In press.

Clements DR, Sterea AM, Kim Y, Helson E, Dean CA, Nunokawa A, Coyle KM, Sharif T, Marcato P, Gujar SA, Lee PWK. Newly recruited CD11b+, GR-1+, Ly6Chigh myeloid cells augment tumor-associated immunosuppression immediately following the therapeutic administration of oncolytic reovirus. Journal of Immunology 2015; 194(9):4397-4412.

Marcato P, Dean CA, Liu R-Z, Coyle KM, Bydoun M, Wallace M, Clements D, Turner C, Mathenge EG, Gujar SA, Giacomantonio CA, Mackey JR, Godbout R, Lee PWK. ALDH1A3 determines breast cancer growth rate via differential retinoic acid signaling. Molecular Oncology 2015; 9(1):17-31.

Rodriguez-Sosa JR, Bondareva A, Tang L, Avelar GF, Coyle KM, Modelski M, Alpaugh W, Conley A, Wynne-Edwards K, França LR, Meyers S, Dobrinski I. Phthalate esters affect maturation and function of primate testis tissue ectopically grafted in mice. Molecular Cellular Endocrinology 2014; 398(1-2):89-100. 

Mathenge EG, Dean CA, Clements D, Vaghar-Kashani A, Photopoulos S, Coyle KM, Giacomantonio M, Maleuth B, Nunokawa A, Jordan J, Gujar SA, Marcato P, Lee PWK, Giacomantonio CA. Core needle biopsy of breast cancer induces immunosuppressive changes, elevated circulating tumor cells and increased metastasis. Neoplasia 2014; 16(11):950-960. 

Thomas ML, Coyle KM, Sultan M, Vaghar-Kashani A, Marcato P. Chemoresistance in cancer stem cells and strategies to overcome resistance. Chemotherapy 2014; 3(1):125.

Coyle KM, Marcato P. Cancer Stem Cells: Clinical Relevance. Canadian Journal of Pathology 2013; 5(4):141-149.

Coyle KM, Sultan M, Thomas ML, Vaghar-Kashani A, Marcato P. Retinoid signaling in cancer and its promise for therapy. Journal of Carcinogenesis and Mutagenesis 2013; S7:006.

Behzad H, Huckriede AL, Haynes L, Gentleman B, Coyle K, Wilschut JC, Kollman TR, Reed SG, McElhaney JE. GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults. Journal of Infectious Diseases 2012; 205:466-373.

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