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  • Dr. Zhaolin Xu, MD, FRCPC, FCAP

Appointments:

Professor, Department of Pathology, Faculty of Medicine, Dalhousie University
Pulmonary Pathologist and Cytopathologist, QE II Health Sciences Centre, CDHA
Chair, Pathology Working Group and Network Member, Pan-Canadian Lung Cancer Screening Network, Canadian Partnership Against Cancer (CPAC)
Chair, Pathology Working Group and Steering Committee Member, Lung Cancer Screening Network, Cancer Care Nova Scotia (CCNS)
Committee Member, Correlative Sciences and Tumor Biology Committee, and Lung Tumor Sub-committee, Clinical Trial Group, National Cancer Institute of Canada (NCIC)
Expert Panel Member, Lung National Cancer Pathology and Staging Multidisciplinary Expert Panel, Canadian Partnership Against Cancer (CPAC)
Medical Advisory Committee Member, Lung Cancer Canada (LCC)

Affiliations:

Dalhousie University, Faculty of Medicine
Queen Elizabeth II Health Sciences Centre, Capital Health

Research Interests:

Lung cancer genotyping and molecular profiling, Lung tumor banking, Metastasis and early detection of lung cancer

Molecular classification of lung cancer is essential in modern oncology

Molecular classification of lung cancer based on gene mutational status has a significant impact on patient’s clinical management that is considered as one of the new directions in modern oncology. Dr. Zhaolin Xu is studying gene mutations in human lung cancer in addition to pathological assessment of the tumor. Lung cancer patients can be divided into various subgroups based on not only tumor morphology but also molecular profiling, and selected to receive personalized targeted therapy accordingly. Dr. Xu and his colleagues have established the QE II Lung Tumor Bank for research since 2005, which is certified by the Canadian Tumor Repository Network (CTRNet). Dr. Xu is the Director of the tumor bank which has become one of the largest human lung tumor banks in the country. Dr. Xu’s research interest also includes lung cancer metastasis and early detection.

Membership Status:

Dr. Xu is a BHCRI Senior Scientist and has been a BHCRI Seminar Series presenter.

Phone:

902-473-7287

Email:

zxu3@dal.ca

Address:

Mackenzie Building, 5788 University Ave., Halifax NS B3H 1V8

Publications:

Yeung P, Xu Z  and Seeto D.  Diltiazem Reduces Mortality and Breakdown of ATP in Red Blood Cell Induced by Isoproterenol in a Freely Moving Rat Model in Vivo   Metabolites 2014, 4: 775-89

MacNeil AJ, Jiao S-C, McEachern LA, Yang YJ, Dennis A, Yu H, Xu Z, Marshall JS, and Lin TJ   MAPK kinase 3 is a tumor suppressor with reduced copy number in breast cancer. Cancer Research  2014; 74(1): 162-72

Xu Z.    Genomics and Molecular Profiling of Lung Cancer in Cancer Genomics: from bench to personalized medicine  eds. G. Dellaire, J. Berman, R. Arceci. Academic Press, Elsevier, 2014

Alcolado N, Conrad DJ, Poroca D, Li M, Alshafie W, Chappe FG, Pelis RM, Anini Y, Xu Z, Hamidi SA, Said SI, Chappe VM.  Cystic Fibrosis Transmembrane Conductance Regulator dysfunction in VIP knockout mice.  American Journal of Physiology - Cell Physiology. 2014, 307(2): C195-207.

Cressman S, Lam S, Tammemagi M, Evans W, Leighl N, Regier D, Bolbocean  C, Shepherd F, Tsao M, Manos D, Liu, Geoffrey, Atkar-Khattra S, Cromwell I, Johnson M, Mayo J, McWilliams A, Couture C, English J, Goffin J, Hwang D, Puksa S, Roberts H, Tremblay A, MacEachern P, Burrowes P, Bhatia R, Finley R, Goss G, Nicholas G, Seely, Jean M, Sekhon H, Yee J, Amjadi K, Cutz J, Ionescu D, Yasufuku K, Martel S, Soghrati K, Sin D, Tan W, Urbanski S, Xu Z, Peacock S. On behalf of the Pan-Canadian Lung Cancer Early Detection Study Team  Resource Utilization and Costs during the Initial Years of Lung Cancer Screening with Computed Tomography in Canada.  Journal of Thoracic Oncology 2014, 9(10): 1449–58.

Xu Z.  Pulmonary Pathology in Pathology Review  ed. Zu-Hua Gao, Brush Educarion Inc. 2013

Andrade-Vieira RP, Xu Z, Colp P and Marignani PA   Loss of lkb1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathways.   Plos One 2013; 8(2): e56567

Marrie TJ, Costain N, La Scola B, Patrick W, Forgie S, Xu Z, McNeil SA. The role of atypical pathogens in community-acquired pneumonia. Semin Respir Crit Care Med. 2012, 33(3):244-56.

Henzler D, Hochhausen H, Chankalal R, Xu Z, Whynot SC, Slutsky A, Zhang H.  Physiologic and biologic characteristics of three experimental models of acute lung injury in rats.  Anesthesia and Analgesia  2011, 112(5):1139-46.

Bethune G, Bethune D, Ridgway N, Xu Z.  Epidermal growth factor receptor (EGFR) in lung cancer: an overview and update.  The Journal of Thoracic Disease  2010, 2:48-51.
    
Xu Z, Bethune D, Manos D, Foyle A, Henteleff H, Johnston M and Cartier Y.  Pulmonary Hyalinizing Granuloma.  Journal of Peking University (Health Sciences) 2009, 4(4):252-257

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