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  • Dr. Xianping Dong, PhD

Appointments:

Associate Professor, Department of Physiology and Biophysics

Affiliations:

Dalhousie University Faculty of Medicine

Research Interests:

ion channel and transporters, calcium signalling, autophagy, lysosomes, lysosomal storage disease, cancer, neurodegenerative disease, bacterial infection.

My primary research interests include lysosome physiology and lysosome-related diseases. Specifically, we study lysosomal ion channels and transporters in cancer progression, lysosomal storage diseases, neurodegenerative diseases and bacterial infection.

Membership Status:

Dr. Dong is a BHCRI Associate Member

Phone:

(902) 494-3370

Email:

xpdong@dal.ca

Website:

medicine.dal.ca/departments/department-sites/physiology/our-people/our-faculty/xianping-dong.html

Address:

4C1, Sir Charles Tupper Medical Bldg, 5850 College Street, Halifax, Nova Scotia, Canada B3H 4R2

Publications:

Sun X, Yang Y, Zhong XZ, Cao Q, Zhu XH, Zhu X, Dong XP. A negative feedback regulation of mTORC1 activity by the lysosomal Ca2+ channel TRPML1 using a calmodulin-dependent mechanism. Autophagy, 2018;14(1):38-52.

Cao Q, Yang Y, Zhong XZ, Dong XP. The lysosomal Ca2+ release channel TRPML1 regulates lysosome size by activating calmodulin. J Biol Chem. 2017; 292(20):8424-8435.

Zhong XZ, Zou Y, Sun X, Dong G Sr, Cao Q, Pandey A, Rainey JK, Zhu X, Dong XP.  Inhibition of TRPML1 by lysosomal adenosine involved in severe combined immunodeficiency diseases.  J Biol Chem. 2017; 292(8):3445-3455

Zhong XZ, Sun X, Cao Q, Dong G, Schiffmann R, Dong XP. BK channel agonist represents a potential therapeutic approach for lysosomal storage diseases. Sci Rep. 2016; 6:33684. 

Zhong XZ, Cao Q, Sun X, Dong XP. Activation of lysosomal P2X4 by ATP transported into lysosomes via SLC17A9 using V-ATPase generated voltage gradient as the driving force.  J Physiol. 2016; 594(15):4253-66. 

Cao Q, Zhong XZ, Zou Y, Murrell-Lagnado R, Zhu MX, and Dong XP. Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion. J Cell Biol, 2015; 209(6):879-94. 

Cao Q, Zhong XZ, Zou Y, Zhang Z, Ligia T, Dong XP. BK Channels Alleviate Lysosomal Storage Diseases by Providing Positive Feedback Regulation of Lysosomal Ca2+ Release. Dev Cell, 2015; 33(4):427-41. 

Cao Q, Zhao K, Zhong XZ, Zou Y, Yu H, Huang P, Xu TL, Dong XP. SLC17A9 Protein Functions as a Lysosomal ATP Transporter and Regulates Cell Viability. J Biol Chem, 2014; 289(33):23189-99. 

Huang P, Zou Y, Zhong XZ, Cao Q, Zhao K, Zhu MX, Murrell-Lagnado R, Dong XP. P2X4 Forms Functional ATP-activated Cation Channels on Lysosomal Membranes Regulated by Luminal pH. J Biol Chem, 2014; 289(25):17658-67.

Dong XP*, Shen D*, Wang X*, Dawson T, Li X, Zhang Q, Cheng X, Zhang Y, Weisman L, Delling M, and Xu H. PI(3,5)P2 controls intracellular membrane traffic by direct activation of mucolipin Ca2+ release channels in the endolysosome. Nature Commun, 2010, 1: 38.


 

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