Dr. Pollen K. Yeung, BSc Pharm, PhD
Professor, College of Pharmacy and Department of Medicine
Pharmacokinetics, Metabolism, Biomarkers, Cardiovascular Protection, Anti-cancer drugs
Although many anti-cancer drugs are highly effective against susceptible cancers in chemotherapy, they are often associated with serious cardiac adverse effects; and resistance to drug therapy may develop after prolonged treatment. It has been postulated that cardiac adverse effects may be reduced by combining them with drugs for treatment of cardiovascular disease. Our research interest is to investigate whether or not combining these anti-cancer drugs with drugs that have known cardiovascular protective effects would improve pharmacokinetics and minimize their cardiovascular toxicities. This will lead to development of novel drug combinations of anti-cancer drugs for cancer chemotherapy, resulting in improved patient outcomes, longer survival rates and better quality of life.
Membership Status:Dr. Yeung is a BHCRI Associate Member and has served as a member of a BHCRI Scientific Review Committee.
Address:Pharmacokinetics and Metabolism Laboratory, College of Pharmacy, Dalhousie University, Halifax, NS, Canada B3H 4R2
Kolathuru SS and Yeung, PKF. Therapeutic Potential of Adenosine Transport Modulators for Cardiovascular Protection (Editorial). Cardiol Pharmacol 4:3 e127, 2015.
Tillman, P and Yeung, PKF. Coenzyme Q10 for cardiovascular prevention (Editorial). Cardiol Pharmacol 3: e125, 2014.
Yeung, PKF, Xu, Z and Seeto, D. Diltiazem Reduces Mortality and Breakdown of ATP in Red Blood Cell Induced by Isoproterenol in a Freely Moving Rat Model in Vivo Metabolites 4: 775 -789, 2014.
Yeung,PKF. ATP Metabolism as Biomarker Target for Cardiovascular Protection (Editorial). Cardiol Pharmacol 2:e118, 2013.
Feridooni, T, MacDonald, C, Shao, Di, Yeung, PKF, Agu, RU Cardio-protective potential of anti-ischemic drugs against chemotherapy-induced cardiotoxicity
in H9C2 cell line. Acta Pharmaceutica 63:493-503, 2013.
Starr, L, Purcell, C and Yeung, P.K. F. Effect of doxorubicin on cardiovascular hemodynamic and RBC concentrations of ATP in rats in vivo. Current Topics in Pharmacology 16:59-65, 2012.
Yeung, PKF, Dauphinee, J and Marcoux, T. Effect of acute exercise on cardiovascular hemodynamic and red blood cell concentrations of purine nucleotides in hypertensive compared with normotensive rats. Therapeutic Advances in Cardiovascular Disease 7(2):63-74, 2013.
Yeung, PKF and Narayanan, S. Hemodynamic effects of cladribine in a restrained rat model. Current Topics in Pharmacology 15 (1): 39 – 42, 2011.
Yeung, PKF, Dauphinee, J, Gouzoules, T, and Simonson, K. and Schindler, C. Exercise improves hemodynamic profiles and increases RBC concentrations of purine nucleotides in a rodent model. Therapeutic Advances in Cardiovascular Diseases 4 (6): 341 – 347, 2010.
Rygier, LC, Yeung, PKF, and Berman, JN. Cladribine inhibits a diltiazem-induced increase in RBC purine nucleotide concentrations in a zebrafish model, Biomarkers 14:554 – 559, 2009.