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  • Dr. Mohamed Touaibia, PhD

Appointments:

Associate Professor

Affiliations:

Department of Chemistry and Biochemistry, Université de Moncton

Research Interests:

Medicinal chemistry, Synthetic Organic Chemistry, Anticancer Drug Development

Anticancer properties of new polyphenols, structure-activity relationship

Our research focuses on the design and synthesis of new anticancer compounds based on natural products. In particular, we synthesise new analogues of caffeic acid. Then in collaboration with biochemists and biologists we evaluate the therapeutic value of these compounds as novel treatments for a range of cancer types.

Membership Status:

Dr. Touaibia is a BHCRI Associate Member

Phone:

(506) 858-4493

Email:

mohamed.touaibia@umoncton.ca

Website:

professeur.umoncton.ca/umcm-touaibia_mohamed/

Address:

Université de Moncton, 18 avenue Antonine-Maillet, Moncton, New Brunswick, Canada, E1A 3E9

Publications:

Doiron J A. , Métayer B, Richard R R, Desjardins D, Boudreau L H, Levesque N A, Jean-François J, Poirier S J, Surette M E, Touaibia M. (2014) Clicked cinnamic/caffeic esters and amides as radical scavengers and 5-lipoxygenase inhibitors. International Journal of Medicinal Chemistry. ID 931756, 1-12.
 
Bhullar K S, Lassalle-Claux G, Touaibia M, Rupasinghe H P V (2014) Antihypertensive effect of caffeic acid and its analogs through dual renin angiotensin aldosterone system inhibition. European Journal of Pharmacology. 730, 125-132.
 
Cuperlovic-Culf, M., Touaibia, M., St-Coeur, P-D, Poitras, J., Morin, P. Jr. et Culf, A. (2014) Metabolic effects of known and novel HDAC and SIRT inhibitors in glioblastomas independently or combined with temozolomide. Metabolites. 4: 807-830.
 
Lefort N, Brown A, Lloyd V, Ouellette R, Touaibia M, Culf AS, Cuperlovic-Culf M. (2014) 1 H NMR metabolomics analysis of the effect of dichloroacetate and allopurinol on breast cancers. Journal of Pharmaceutical and Biomedical Analysis. 93, 77-85.

Sanderson J T, Clabault H, Patton C, Lassalle-Claux G, Jean-François J, Paré A F, Hébert M J.G., Surette M E, Touaibia M (2013) Antiproliferative, antiandrogenic and cytotoxic effects of novel caffeic acid derivatives in LNCaP human androgen-dependent prostate cancer cells. Bioorg. Med. Chem. 21, 7182-7193.

St-Coeur PD, Ferguson D, Morin P Jr, Touaibia M, (2013) PF-8380 and Closely Related Analogs: Synthesis and Structure-Activity Relationship towards Autotaxin Inhibition and Glioma Cell Viability. Arch. Pharm. Chem. Life Sci. 346, 91-97.

Morin P Jr; Ferguson, D; LeBlanc, L M.; Hebert, M J. G.; Pare, A F.; Jean-Francois, J; Surette, M E.; Touaibia, M; Cuperlovic-Culf, M. (2013) NMR Metabolomics Analysis of the Effects of 5-Lipoxygenase Inhibitors on Metabolism in Glioblastomas. J. Prot. Res. 12(5), 2165-2176.

St-Coeur PD, Touaibia M, Cuperlovic-Culf M, Morin PJr. (2013) Leveraging Metabolomics to Assess the Next Generation of Temozolomide-based Therapeutic Approaches for Glioblastomas. Genomics Proteomics Bioinformatics. 11, 199-206.

Cuperlovic-Culf M, Ferguson D, Culf AS, Morin P Jr, Touaibia M. (2012) 1H NMR metabolomics analysis of glioblastoma subtypes: correlation between metabolomics and gene expression characteristics. J Biol Chem. 287(24):20164-75.

Cuperlovic-Culf, M ; Culf, AS ; Touaibia, M; Lefort, N. (2012) Targeting the latest hallmark of cancer: another attempt at 'magic bullet' drugs targeting cancers' metabolic phenotype. Future Oncology, 8(10), 1315-1330.

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