Dr. Mani Larijani, PhD
Assistant professor of Immunology and Infectious Diseases, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland
cross-appointed to the Discipline of Oncology, Faculty of Medicine, Memorial University of Newfoundland
Memorial University of Newfoundland
My lab is interested in how processes that change DNA sequence are involved in the transformation of healthy cells to cancer.
Mechanisms of genome mutators involved in cancer
Maintaining the fidelity and integrity of genomic DNA is a biological rule. The exception occurs in the immune system where lymphocytes actively damage their genes in order to become more effective at an immune response. While necessary for an optimal immune response, these processes can lead to cancer. Our research is focused on understanding the mechanistic features of these genome-mutating processes, how they are regulated in cells and how they lead to transformation of healthy cells into tumors.
Membership Status:Dr. Larijani is a BHCRI Senior Scientist and is a CRTP supervisor.
Address:Room 1809A, Health Science Centre, 300 Prince Philips Drive, St. John’s, NL, A1B 3V6.
Abdouni H, King J, Suliman Mw , Quinlan M , Fifield H, Larijani M. Zebrafish AID is capable of deaminating methylated deoxycytidines. Nucleic Acids Research. 2013. 1;41(10):5457-68
Abdelfatah, N, McComiskey, D, Griffin, A , Moore, S , Negrijn, C , Hodgkinson, K , King, J , Larijani, M , Houston, J , Doucette, L , Stanton, S, Young, T. Identification of a novel in-frame deletion in KCNQ4 (DFNA2A) and a convincing case of phenocopies in a multiplex family with variable ADSNHL. Eur J Hum Genet. 2013 Feb 27.
Martin, A, Larijani M. The Biochemistry of Activation-Induced Deaminase and its physiological functions. Seminars in Immunology 2012. Jun 11.
Monajemi M, Woodworth C, Benkaroun J, Grant M, Larijani M. Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment. Retrovirology 2012 Apr 30;9(1):35.
Dancyger, A, King J, Quinlan M, Fifield H, Tucker S, Saunders H, Berru M, Magor B, Martin A, Larijani M. Differences in the enzymatic efficiency of bony fish and human AID are mediated by a single residue in the C-terminus that modulates single-stranded DNA binding. FASEB J. 2012. Apr;26(4):1517-25.
Fritz JH, Rojas O, Simard N, McCarthy D, Hapfelmeier S, Rubino S, Robertson S, Larijani M, Gosselin J, Ivanov I, Martin A, Casellas R, Philpott D, Girardin SE, McCoy KD, Macpherson AJ, Paige CJ, and. Gommerman JL. Acquisition of a multifunctional TNFa/iNOS-producing IgA+ plasma cell phenotype in the gut. Nature. 2011. 481(7380):199-203.
Duvvuri B, Duvvuri, VR, Grigull J, Martin, Pan-Hammerstrom Q, Wu GE, Larijani M. Altered spectrum of somatic hypermutation in Common Variable Immunodeficiency Disease characteristic of defective repair of mutations. Immunogenetics. 2011. 63(1):1-11.