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  • Dr. Luc Boudreau, PhD

Appointments:

Assistant Professor

Affiliations:

Université de Moncton

Research Interests:

Extracellular vesicles, microparticles, mitochondria, inflammation

Role of extracellular vesicles in inflammatory diseases

In my laboratory, we investigate the role of small cells (microparticles) in promoting inflammatory diseases, including cancer. These small cells communicate with the microtumor environment. Our research aims to establish a link between these small cells and their ability to promote tumor growth.

Membership Status:

Dr. Boudreau is a BHCRI Associate Member

Phone:

(506)-858-4207

Email:

luc.boudreau@umoncton.ca

Website:

professeur.umoncton.ca/umcm-boudreau_luc/

Address:

Université de Moncton, Rémi-Rossignol, room A214, Moncton, NB, E1A 3E9

Publications:

Fidler, T. P., Rowley, J. W., Araujo, C., Boudreau, L. H., Marti, A., Souvenir, R., et al. (2017). Superoxide Dismutase 2 is dispensable for platelet function. Thrombosis and Haemostasis, 117(10), 1859–1867. http://doi.org/10.1160/TH17-03-0174 

Boudreau, L. H., Lassalle-Claux, G., Cormier, M., Blanchard, S., Doucet, M. S., Surette, M. E., & Touaibia, M. (2017). New Hydroxycinnamic Acid Esters as Novel 5-Lipoxygenase Inhibitors That Affect Leukotriene Biosynthesis. Mediators of Inflammation, 2017, 6904634–12. http://doi.org/10.1155/2017/6904634 

Fidler, T. P., Middleton, E., Rowley, J. W., Boudreau, L. H., Campbell, R. A., Souvenir, R., et al. (2017). Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arteriosclerosis, Thrombosis, and Vascular Biology, ATVBAHA.117.309184. http://doi.org/10.1161/ATVBAHA.117.309184 

Batoul Benyelles, Hocine Allali, Mohamed Touaibia, Nadia Fekih, Luc H. Boudreau and Marc E. Surette. Antioxidant and anti-inflammatory activities of the volatile components of Tropaeolum majus L. (Garden Nasturtium) from north western Algeria. Journal of Pharmaceutical, Chemical and Biological Sciences (2016) 

Geneviève Marcoux, Anne-Claire Duchez, Mattieu Rousseau, Tania Lévesque, Luc H. Boudreau, Louis Thibault, Eric Boilard. Microparticle and mitochondrial release during extended storage of different types of platelet concentrates. Platelets. 2016 Sep 29:1-9.PMID: 27681879 

Philippe-Pierre Robichaud, Samuel J Poirier, Luc H. Boudreau, Eric Boilard, Marc E Surette. On the cellular metabolism of the click chemistry probe 19-alkyne arachidonic acid. J Lipid Res. 2016 Oct;57(10):1821-1830. PMID: 27681879 

Eric Allain, Luc H. Boudreau, Nicolas Flamand and Marc E. Surette. The intracellular localisation and phosphorylation profile of the human 5-lipoxygenase -13 isoform differs from that of its wild-type counterpart. PLoS One. 2015 Jul 14;10(7):e0132607. doi: 10.1371/journal.pone.0132607 PMID: 26173130 

Anne-Claire Duchez, Luc H. Boudreau, Jim Bollinger, Clémence Belleannée, Nathalie Cloutier, Benoit Laffont, Raifish Mendoza, Tania Lévesque, Emmanuelle Rollet-Labelle, Matthieu Rousseau, Isabelle Allaeys, Jacques J. Tremblay, Patrice E. Poubelle, Gérard Lambeau, Marc Pouliot, Patrick Provost, Denis Soulet, Michael H. Gelb and Eric Boilard. Platelet microparticles self-promote their internalization and the transfer of their elaborated cargo in neutrophils via 12-lipoxygenase. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3564-73. doi: 10.1073/pnas.1507905112. 

Luc H. Boudreau, Geneviève Marcoux and Eric Boilard Platelet microparticles in transfusion (2015) ISBT Science Series, 10 (S1), 305-308 

Luc H. Boudreau, Anne-Claire Duchez, Nathalie Cloutier, Denis Soulet, Nicolas Martin, James Bollinger, Alexandre Paré, Matthieu Rousseau, Gajendra S. Naika, Tania Lévesque, Cynthia Laflamme, Geneviève Marcoux, Gérard Lambeau, Richard W. Farndale, Carolina Landolt-Marticorena, Marc Pouliot, Hind Hamzeh-Cognasse, Fabrice Cognasse, Olivier Garraud, Paul R. Fortin, Peter A. Nigrovic, Helga Guderley, Steve Lacroix, Louis Thibault, John W. Semple, Michael H. Gelb and Eric Boilard. Platelets release mitochondria serving as substrate for bactericidal group IIA secreted phospholipase A2 to promote inflammation. Blood. 2014 Oct 2;124(14):2173-83. PMID: 25082876 

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