Dr. Jun Wang, Ph.D
Assistant Professor, Departments of Microbiology & Immunology, Pediatrics, and Pathology, Dalhousie University
Canadian Center for Vaccinology, IWK Health Centre, Dalhousie University
IL-17, IL-17R, adenovirus, breast cancer, adaptive immunity
Targeting on the IL-17/IL-17R axis
The immune system plays a vital role in disease control; however, inappropriate immune responses also contribute to the development and progression of many diseases. My research aims to (1) understand the role of the IL-17/IL-17R axis in regulating host resistance against infections caused by Chlamydia species; (2) dissect the contribution of the IL-17/IL-17R axis in breast tumorigenesis; and (3) develop prophylactic and/or therapeutic vaccines against infection and cancer using a recombinant adenoviral delivery system.
Membership Status:Dr. Wang is a BHCRI Associate Member who has served as a member of a BHCRI Scientific Review Committee.
Address:Canadian Center for Vaccinology IWK Health Centre Goldbloom Research and Clinical Care Pavilion, 3rd Floor West 5850/5980 University Avenue Halifax, NS B3K 6R8 Canada
Zhou X, Chen RQ, Moore JM, Kolls JK, Halperin S, Wang J. Critical role of IL-17/IL-17R axis in regulating host susceptibility to respiratory Chlamydia infection. Infect Immun. 2009;77:5059-5070.
Xing Z, Christine T. McFarland, Jean-Michel Sallenave, Angelo Izzo, Jun Wang, McMurray DN. Intranasal mucosal boosting with an adenovirus-vectored vaccine markedly enhances the protection of BCG-primed guinea pigs against pulmonary tuberculosis. PLoS ONE. 2009;4(6):e5856.
Zhang X, Divangahi M, Ngai P, Santosuosso M, Miller M, Zganiacz A, Wang J, Bramson J, Xing Z. Intramuscular immunization with a monogenic plasmid DNA tuberculosis vaccine: Enhanced immunogenicity by electroporation and co-expression of GM-CSF transgene. Vaccine. 2007;25(7):1342-1352.
Yan SR, Joseph RR, Wang J, Stadnyk AW. Differential pattern of inflammatory molecule regulation in intestinal epithelial cells stimulated with IL-1. J Immunol. 2006;177:5604-5611.
Malowany JI, McCormick S, Santosuosso S, Zhang X, Aoki N, Ngai P, Wang J, Leitch J, Bramson J, Wan Y, Xing Z. Development of cell-based tuberculosis vaccines: genetically modified dendritic cell vaccine is a much more potent activator of CD4 and CD8 T cells than peptide- or protein-loaded counterparts. Mol Ther. 2006;13(4):766-775.
Huaux F, Gharaee-Kermani M, Liu T, Morel V, McGarry B, Ullenbruch M, Kunkel SL, Wang J, Xing Z, Phan SH. Role of Eotaxin-1 (CCL11) and CC chemokine Receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis. Am J Pathol. 2005;167:1485-1496.
Santosuosso M, Zhang X, McCormick S, Wang J, Hitt M, Xing Z. Mechanisms of mucosal and parenteral tuberculosis vaccinations: adenoviral-based mucosal immunization preferentially elicits sustained accumulation of immune protective CD4 and CD8 T cells within the airway lumen. J Immunol. 2005;174:7986-7994.
Wang J, Thorson L, Stokes RW, Santosuosso M, Huygen K, Zganiacz A, Hitt M, Xing, Z. Single mucosal, but not parenteral, immunization with recombinant adenoviral-based vaccine provides potent protection from pulmonary tuberculosis. J Immunol. 2004;173:6357-6365.
Wang J, Santosuosso M, Zganiacz A, Xing, Z. Activation of CD8 T cells by mycobacterial vaccination protects against pulmonary tuberculosis in the absence of CD4 T cells. J Immunol. 2004;173:4590-4597.
Zganiacz A, Santosuosso M, Wang J, Yang T, Anzulovic M, Chen L, Alexander S, Gicquel B, Wan Y, Bramson J, Inman M, Xing Z. TNF? is a critical negative regulator of type 1 immune activation during intracellular bacterial infection. J Clin Invest. 2004;113:401-413.