The Beatrice Hunter Cancer Research Institute logo
  • Dr. Jennifer Corcoran, PhD

Appointments:

Assistant Professor

Affiliations:

Departments of Microbiology and Immunology and Surgery, Dalhousie University

Research Interests:

KSHV, Kaposin B, endothelium, actin, RhoA, MK2, processing bodies

Viral Targeting of a Central Node of Control in the Endothelium Promotes Kaposi’s Sarcoma

Kaposi’s sarcoma associated herpesvirus (KSHV) selectively targets and persists in the endothelium; the resulting EC reprogramming leads to marked inflammation and the formation of multiple polyclonal, angioproliferative Kaposi’s sarcoma (KS) tumours. I have recently reported that the viral oncoprotein, Kaposin B (KapB), is a key mediator of KSHV-induced EC reprogramming by altering the MK2-RhoA signalling axis. As a result, KapB modifies cytoskeletal dynamics, autophagic flux, processing body homeostasis, mRNA turnover, and inflammatory gene expression.

Membership Status:

Dr. Jennifer Corcoran is a BHCRI Associate Member and a CRTP trainee supervisor.

Phone:

(902) 494-6296

Email:

jcorcora@dal.ca

Address:

5850 College Street, Tupper Room 10G, PO Box 1500, Halifax, NS, Canada, B3H 4R2

Publications:

Hilchie, A. L., A. J. Sharon, E. F. Haney, D. W. Hoskin, M. B. Bally, O. Franco, J. A. Corcoran and R. E. Hancock. 2016. Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma. BBA-Biomembranes. 1858(12):3195-3204.

Corcoran, J. A.* and C. McCormick. 2015. A novel signaling axis and new role for RhoA GTPase in post-transcriptional gene expression control. Small GTPases. 6(4):178-85. Review * corresponding author

Corcoran, J. A., B. P. Johnston and C. McCormick. 2015. Viral activation of MK2-hsp27-p115RhoGEF-RhoA signaling axis causes cytoskeletal rearrangements, p-body disruption and ARE-mRNA stabilization. PLOS Pathogens. 11(1): e1004597.

Corcoran, J. A., D. Khaperskyy, B. P. Johnston, C.A. King, D.P. Cyr, A.V. Olsthoorn, and C. McCormick. 2012. Kaposi’s sarcoma-associated herpesvirus G-protein coupled receptor prevents AU-rich element-mediated decay. J. Virol. 86(16): 8859-8871.

Corcoran, J. A., D. A. Khaperskyy, and C. McCormick. 2011. Assays for monitoring viral manipulation of host ARE-mRNA turnover. Methods 55(2): 172-181. 

Site by: Spectacle Group