Dr. Jennifer Corcoran, PhD
Departments of Microbiology and Immunology and Surgery, Dalhousie University
KSHV, Kaposin B, endothelium, actin, RhoA, MK2, processing bodies
Viral Targeting of a Central Node of Control in the Endothelium Promotes Kaposi’s Sarcoma
Kaposi’s sarcoma associated herpesvirus (KSHV) selectively targets and persists in the endothelium; the resulting EC reprogramming leads to marked inflammation and the formation of multiple polyclonal, angioproliferative Kaposi’s sarcoma (KS) tumours. I have recently reported that the viral oncoprotein, Kaposin B (KapB), is a key mediator of KSHV-induced EC reprogramming. KapB targets a newly described nodal signaling axis, linking the kinase mitogen-activated protein kinase-activated protein kinase 2 (MK2) to the small cytoskeletal regulatory GTPase, RhoA.
Membership Status:Dr. Jennifer Corcoran is a BHCRI Associate Member and a CRTP trainee supervisor.
Address:5850 College Street, Tupper Room 10G, PO Box 1500, Halifax, NS, Canada, B3H 4R2
Corcoran, J. A., B. P. Johnston and C. McCormick. 2015. Viral activation of MK2-hsp27-p115RhoGEF-RhoA signaling axis causes cytoskeletal rearrangements, p-body disruption and ARE-mRNA stabilization. PLOS Pathogens. 11(1): e1004597.
Corcoran, J.A., D. Khaperskyy, B. P. Johnston, C.A. King, D.P. Cyr, A.V. Olsthoorn, and C. McCormick. 2012. Kaposi’s sarcoma-associated herpesvirus G-protein coupled receptor prevents AU-rich element-mediated decay. J. Virol. 86(16): 8859-8871.
Corcoran, J. A., D. A. Khaperskyy, and C. McCormick. 2011. Assays for monitoring viral manipulation of host ARE-mRNA turnover. Methods 55(2): 172-181.
Corcoran, J. A., E. K. Clancy, and R. Duncan. 2011. Homomultimerization of the reovirus p14 FAST protein during transit through the ER-golgi secretory pathway is pH-sensitive. J. Gen. Virol. 92:162-166
Corcoran, J. A., H. A. Saffran, B. A. Duguay and J. R. Smiley. 2009. Herpes simplex virus UL12.5 targets mitochondria through a mitochondrial localization sequence proximal to the N-terminus. J. Virol. 83:2601-10.