Dr. Jennifer Corcoran, PhD
Departments of Microbiology and Immunology and Surgery, Dalhousie University
KSHV, Kaposin B, endothelium, actin, RhoA, MK2, processing bodies
Viral Targeting of a Central Node of Control in the Endothelium Promotes Kaposi’s Sarcoma
Kaposi’s sarcoma associated herpesvirus (KSHV) selectively targets and persists in the endothelium; the resulting EC reprogramming leads to marked inflammation and the formation of multiple polyclonal, angioproliferative Kaposi’s sarcoma (KS) tumours. I have recently reported that the viral oncoprotein, Kaposin B (KapB), is a key mediator of KSHV-induced EC reprogramming by altering the MK2-RhoA signalling axis. As a result, KapB modifies cytoskeletal dynamics, autophagic flux, processing body homeostasis, mRNA turnover, and inflammatory gene expression.
Membership Status:Dr. Jennifer Corcoran is a BHCRI Associate Member and a CRTP trainee supervisor.
Address:5850 College Street, Tupper Room 10G, PO Box 1500, Halifax, NS, Canada, B3H 4R2
Hilchie, A. L., A. J. Sharon, E. F. Haney, D. W. Hoskin, M. B. Bally, O. Franco, J. A. Corcoran and R. E. Hancock. 2016. Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma. BBA-Biomembranes. 1858(12):3195-3204.
Corcoran, J. A.* and C. McCormick. 2015. A novel signaling axis and new role for RhoA GTPase in post-transcriptional gene expression control. Small GTPases. 6(4):178-85. Review * corresponding author
Corcoran, J. A., B. P. Johnston and C. McCormick. 2015. Viral activation of MK2-hsp27-p115RhoGEF-RhoA signaling axis causes cytoskeletal rearrangements, p-body disruption and ARE-mRNA stabilization. PLOS Pathogens. 11(1): e1004597.
Corcoran, J. A., D. Khaperskyy, B. P. Johnston, C.A. King, D.P. Cyr, A.V. Olsthoorn, and C. McCormick. 2012. Kaposi’s sarcoma-associated herpesvirus G-protein coupled receptor prevents AU-rich element-mediated decay. J. Virol. 86(16): 8859-8871.
Corcoran, J. A., D. A. Khaperskyy, and C. McCormick. 2011. Assays for monitoring viral manipulation of host ARE-mRNA turnover. Methods 55(2): 172-181.