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  • Dr. Jeanette Boudreau, PhD

Appointments:

Assistant Professor, Department of Microbiology and Immunology

Affiliations:

Dalhousie University

Research Interests:

Natural Killer cells, NK immunogenetics, cancer gene and expression profiling, bioinformatics 

Precision natural killer cell therapy

Cancer results when mutations in a person’s DNA drive uncontrolled growth of a population of cells. Therefore, even with many common features, cancer is a unique disease in each patient. The Boudreau laboratory is defining the features of tumours that result from genetic mutations that can be targeted by a population of white blood cells called natural killers (NK), aiming to develop NK cells as precise effectors for immunotherapy. 

Membership Status:

Dr. Jeanette Boudreau is a BHCRI Associate Member.

Phone:

(902) 494 4536

Email:

Jeanette.boudreau@dal.ca

Website:

medicine.dal.ca/departments/department-sites/microbiology/people/our-faculty/jeanette-boudreau.html

Address:

Sir Charles Tupper Medical Building, Dalhousie University, 5850 College Street, P.O. Box 15000, Halifax, Nova Scotia, Canada B3H 4R2

Publications:

Boudreau JE, Giglio F, Gooley TA, Stevenson PA, Le Luduec JB, Rajalinam R, Hou L, Katovich Hurley C, Lebedeva T, Noreen H, Reed EF, Yu N, Vierra-Green C, Haagenson MD, Malkki M, Petersdorf EW, Spellman S, Hsu KC. Donor KIR3DL1 and HLA-B subtype combinations predict acute myelogenous leukemia control after HLA9compatible hematopoietic cell transplantation. J Clin Oncol, 2017 Jul 10;35(20):2268-2278

Boudreau JE, Liu XR, Zhao Z, Zhang A, Schultz LD, Greiner DL, Dupont B, Hsu KC. Cell-extrinsic MHC class I molecule engagement augments human NK cell education programmed by cell-intrinsic MHC class I. Immunity, In Press. 

Forlenza CJ, Boudreau JE, Zheng J, Heller G, Cheung NKV, Hsu KC. KIR3DL1 allelic polymorphism and affinity for HLA-Bw4 epitopes modulates response to anti-GD2 monoclonal antibody in patients with neuroblastoma. J Clin Oncol, ePub April 11, 2016.

Xiu F, Anipindi VC, Nguyen PV, Boudreau J, Liang H, Wan YH, Snider DP, Kaushic K. High physiological concentrations of progesterone reverse estradiol-mediated changes in differentiation and functions of bone marrow derived dendritic cells. PLOS ONE, 2016 Apr 11(4):e0153304.

Boudreau JE, Le Luduec JB, Mulrooney TJ, Hsu KC. Receptor and ligand density calibrate NK responsiveness: implications for HIV control. J Immunol, 2016 Mar 9 (ePub).

Boudreau JE, Wouters MC, Krawczyk CM. 8th Annual Canadian Cancer Immunotherapy Consortium (CCIC) Symposium 2015-May 20-22, Vancouver, Canada. Cancer Immunol Immunother. 2016 Feb;65(2):235-41

Mulrooney TJ, Zhang A, Goldgur Y, Boudreau JE, Hsu KC. KIR3DS1 specific D0 domain polymorphisms disrupt KIR3DL1surface expression and HLA binding. J Immunol. 2015 Aug 1;195(3):1242-50. 

Karimi K, Karimi Y, Chan J, Boudreau JE, Bassett JD, Chew M, Reid S, Bramson JL, Wan YH, Ashkar AA. Type I IFN signaling on dendritic cells is required for NK cell-mediated anti-tumor immunity. Innate Immunity. Epub March 2015.

Boudreau JE, Le Luduec JB, Hsu KC. Development of a novel multiplex PCR assay to detect functional subtypes of KIR3DL1 alleles. PLOS ONE, 2014 Jun 11;9(6):e99543.

Zhang L, Bridle BW, Chen L, Pol J, Spaner D, Boudreau JE, Rosen A, Bassett JD, Lichty BD, Bramson JL Wan Y. Delivery of viral vectored vaccines by B cells represents a novel strategy to accelerate CD8+ T cell recall responses. Blood, 2013 Mar; 121(13): 2432-9. ePub 2013 Jan 16. 

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