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  • Dr. Etienne Hébert Chatelain, PhD

Appointments:

Assistant Professor, Biology, Department of Biology, Université de Moncton

Affiliations:

Université de Moncton

Research Interests:

Mitochondria, cellular signaling, Phosphoproteome, Src kinase, Breast cancer

Targeting the mitochondrial phosphoproteome in cancer

Phosphorylation of mitochondrial proteins emerged as a powerful regulation pathway of cellular homeostasis. My team aims to understand the importance of these processes in the development of different pathologies including breast cancer. Notably, we focus on intra-mitochondrial Src kinase which is hyperactivated in several types of cancer. The characterization of the mitochondrial phosphoproteome in different models of cancer will allow my team to establish these events as therapeutic targets for breast cancer.  

Membership Status:

Dr. Etienne Hébert Chatelain is an Associate Member

Phone:

(506) 858-4452

Email:

etienne.hebert.chatelain@umoncton.ca

Address:

Pavillon Rémi-Rossignol, Université de Moncton, 18 Av. Antonine-Maillet, Moncton, New Brunswick, Canada, E1A 3E9

Publications:

Hebert-Chatelain E, Reguero L, Puente N, Lutz B, Chaouloff F, Rossignol R, Piazza P-V, Benard G, Grandes P et Marsicano G. (2014). Studying mitochondrial CB1 receptors : yes we can. Molecular Metabolism 3: 339.

Hebert-Chatelain E, Reguero L, Puente N, Lutz B, Chaouloff F, Rossignol R, Piazza P-V, Benard G, Grandes P et Marsicano G. (2014). Cannabinoid control of brain bioenergetics: exploring the subcellular localization of CB1 receptors? Molecular Metabolism 3: 495-504. 

Vallée M, Hébert-Chatelain E*, Vitiello S*, Bellocchio L*, Monlezun S*, Martin-Garcia E, Kasanetz F, Baillie G L, Panin F, Cathala A, Roullot-Lacarrière V, Fabre S, Hurst D P, Lynch D L, Shore D M, Deroche-Gamonet V, Spampinato U, Revest J-M, Maldonado R, Reggio P H, Ross R A, Marsicano G et Piazza P V. (2013). Pregnenolone Can Protect the Brain from Cannabis Intoxication. Science 343: 93-98.

Bosier B, Bellochio L, Metna-Laurent M, Soria-Gomez E, Matias I, Hebert-Chatelain E, Cannich A, Maitre M, Leste-Lassere T, Cardinal P, Mendizabal-Zubiaga J, Canduela M J, Reguero L, Hermans E, Grandes P, Cota D et Marsicano G. (2013) Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes. Molecular Metabolism. 2: 394-404. 

Melser S, Hebert-Chatelain E*, Lavie J*, Jose C, Giraud E, Goorden S, Priault M. Elgersma Y, Rezvani H, Rossignol R, Bénard G. (2013) Rheb regulates mitochondrial degradation-induced by energy status. Cell Metabolism. 17: 719-730. 

Hebert-Chatelain, E. (2013) Src kinases are important regulators of mitochondrial functions. The International Journal of Biochemistry and Cell Biology. 45 (1): 90-98. 

Hebert-Chatelain E, Jose C, Gutierrez Cortes N, Dupuy J-W, Rocher C, Dachary-Prigent J, Letellier T. (2012) Preservation of NADH ubiquinone oxidoreductase activity by Src kinase-mediated phosphorylation of NDUFB10. Biochimica and Biophysica Acta. 1817: 718-725. 

Benard G, Massa F, Puente N, Lourenco J, Bellochio L, Soria-Gomez E, Matias I, Delamarre A, Metna-Laurent M, Cannich A, Hebert-Chatelain E, Mulle C, Ortega-Gutierrez S, Martin-Fontecha M, Klugmann M, Guggenhuber S, Lutz B, Gertsch J, Chaouloff F, Lopez-Rodriguez M, Grandes P, Rossignol R, Marsicano G. (2012) Mitochondrial CB1 receptors regulate neuronal energy metabolism. Nature Neurosciences. 15: 558-564. 

Gutiérrez-Cortés N, Pertuiset C, Dumon E, Börlin M, Hebert-Chatelain E, Pierron D, Feldmann D, Jonard L, Marlin S, Letellier T, Rocher C. (2012) Novel mitochondrial DNA mutations responsible for maternally inherited non-syndromic hearing loss. Human Mutations. 33: 681-689. 

Jose C, Bellance N, Chatelain EH, Benard G, Nouette-Gaulain K, Rossignol R. (2012) Antiproliferative activity of levobupivacaine and aminoimidazole carboxamide ribonucleotide on human cancer cells of variable bioenergetic profile. Mitochondrion. 12: 100-109.

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