The Beatrice Hunter Cancer Research Institute logo
  • Dr. Denis J. Dupré, PhD

Appointments:

Associate Professor, Department of Pharmacology

Affiliations:

Faculty of Medicine, Dalhousie University

Research Interests:

G protein coupled receptors, chemokines, signal transduction, protein-protein interaction, signaling complex assembly, trafficking and chaperones involved in assembly

Understanding how chemokine receptors contribute to cancer development and metastasis

90% of cancer mortality is associated with the spread of tumor cells. Several cellular factors have been shown to be important for metastasis, including proteins at the surface of tumor cells like CXCR4. In the Dupré lab, we identify and characterize proteins that change the way CXCR4 produces signals, with the goal of identifying new anti-metastasis drug targets.

Membership Status:

Dr. Dupré is a BHCRI Senior Scientist

Phone:

(902) 494-2550

Email:

denis.dupre@dal.ca

Website:

myweb.dal.ca/dn728932

Address:

Sir Charles Tupper Medical Building, Dalhousie University, 5850 College Street, P.O. Box 15000, Halifax, Nova Scotia, Canada B3H 4R2

Publications:

Gillies K, Wertman J, Charette N, Dupré DJ. Anterograde Trafficking of CXCR4 and CCR2 Receptors in a Prostate Cancer Cell Line. Cell Physiol Biochem. 2013
Jul 5;32(1):74-85.

Langelaan DN, Reddy T, Banks AW, Dellaire G, Dupré DJ, Rainey JK. Structural features of the apelin receptor N-terminal tail and first transmembrane
segment implicated in ligand binding and receptor trafficking. BBA – Biomembranes 2013 Feb 22;1828(6):1471-1483

Wertman J, Dupré DJ, G protein-coupled receptor dimers: Look like their parents, but act like teenagers! J Recept Signal Transduct Res. 2013 Jun;33
(3):135-8

Dupré DJ, Hammad MM, Holland P, Wertman J, Role of chaperones in G protein coupled receptor signaling complex assembly, GPCR Signalling Complexes –
Synthesis, Assembly, Trafficking and Specificity, Springer Subcellular Biochemistry Series 63, chapter 2, 23-42

Dupré DJ, Rola-Pleszczynski M, Stankova J, Rescue of internalization-defective platelet-activating factor receptor function by EBP50/NHERF1. J Cell Commun
Signal. 2012 Dec;6(4):205-16

Kuang YQ, Charette N, Frazer J, Holland PJ, Attwood KM, Dellaire G, Dupré DJ, Dopamine receptor interacting protein 78 acts as a molecular chaperone for
chemokine receptors signaling complex organization. PLoS ONE 2012 7(7): e40522

Hammad MM, Kuang YQ, Morse A, Dupré DJ, Rab1 interacts directly with beta2-adrenergic receptor to regulate receptor anterograde trafficking. Biological
Chemistry, 2012 May 1;393(6):541-6

Deyts C, Vetrivel KS, Shepherd YM, Dupré DJ, Thinakaran G, Parent AT: Novel GalphaS-protein signaling associated with membrane-tethered APP intracellular
domain. Journal of Neuroscience 2012 Feb1 32(5) 1714-1729

Kuang YQ, Pang W, Zheng YT, Dupré DJ: NHERF1 regulates gp120-induced internalization and signaling by CCR5, and HIV-1 production. European Journal of
Immunology, 2012 Feb;42(2):299-310

Charette N, Holland P, Frazer J, Allen H, Dupré DJ: Dependence on Different Rab GTPases for the Trafficking of CXCR4 and CCR5 Homo or Heterodimers Between
the Endoplasmic Reticulum and Plasma Membrane in Jurkat Cells. Cellular Signalling (2011) 23, 1738–1749.

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