Dr. Andrew William Stadnyk, PhD
Professor, Departments of Pediatrics and Microbiology & Immunology, Faculty of Medicine and Faculty of Graduate Studies, Dalhousie University;
Scientific Staff, IWK Health Centre
Dalhousie University; IWK Health Centre
colitis, colon carcinoma, colorectal cancer; inflammatory bowel disease, chronic inflammation, detachment-induced cell death; anoikis, epithelial cell pathophysiology
Chronic inflammatory diseases pre-dispose to carcinoma
Patients with unremitting inflammatory bowel disease (IBD) are at increased risk of developing intestinal carcinoma, including colorectal cancer. My cancer research focus is on understanding the processes that contribute to this risk in IBD. For example, we recently discovered that tumor necrosis factor, a target in the prevention of inflammation, also directly contributes to cancer development. I am
also working to reduce the mucosal damage that cancer therapeutics cause, in order to improve patient responses.
Membership Status:Dr. Stadnyk is a Senior Scientist of BHCRI and a former Chair of the BHCRI Scientific Review Committee.
Address:Mucosal Immunology Research, IWK Health Centre 8W, 5850 University Avenue, Halifax, NS, Canada, B3K 6R8
Jain, U., Woodruff, T. and Stadnyk, A.W. The C5a receptor antagonist PMX205 ameliorates experimentally induced colitis associated with increased
IL-4 and IL-10. British Journal of Pharmacology 168:488-501, 2013.
Stillie, R.M., Sapp, H. and Stadnyk, A.W. TNFR1 deficiency protects mice from colitis-associated colorectal cancer coupled with a decreased level of oxidative
damage in the colon: implications for anti-TNF therapy of unremitting colitis. Journal of Cancer Therapy 3(6A):926-940, 2012.
McIsaac, S.M., Stadnyk, A.W., and Lin, T.-J. Toll-like receptors in the host defense against Pseudomonas aeruginosa respiratory infection and cystic fibrosis.
Journal of Leukocyte Biology 92:977-985, 2012.
Cao, Q., McIsaac, S.M. and Stadnyk, A.W. Human colonic epithelial cells detect and respond to complement activation via expression of the anaphylatoxin receptor
C5aR. American Journal of Physiology: Cell Physiology 302:C1731-1740, 2012.
Farooq, S.M. and Stadnyk, A.W. Neutrophil infiltration of the colonic mucosa is independent of the FPR1 yet FPR1 deficient mice show differential
susceptibilities to acute versus chronic DSS colitis. Digestive Diseases and Sciences 57:1802-1812, 2012.
Stadnyk, A.W., Carrigan, S.O., and Otley, A.R. Neutrophil transintestinal epithelial migration to CXCR2 ligands is regulated by adenosine. Journal of Pediatric
Gastroenterology and Nutrition 54:414-421, 2012.