Dr. Tong-Jun Lin, MD, PhD
Professor, Departments of Microbiology & Immunology and Pediatrics
Scientific Staff, IWK Health Centre
Dalhousie University Faculty of Medicine, IWK Health Centre
Host defense, signal transduction; regulation of gene transcription, inflammation, toll-like receptors, Fc receptors, mast cells, macrophages, regulatory T cells, innate immunity.
Understanding mechanisms of cancer cell death and enhancing anti-tumor immunity
Major obstacles in cancer therapy include the resistance of cancer cells to death signals and the inablity of immune cells to recognize and kill tumor cells, which may act in concert to counteract effective anti-tumor immune response. Dr Tong-Jun Lin and his team are studying two specific forms of cell death, namely apoptosis and autophagy. They are also studying how immune cells detect the danger signals which include signals from tumors. Their goal is to better understand the mechanisms of cell death and to enhance anti-tumor immunity by targeting both cancer cells and immune cells.