Dr. Paola Marignani, MSc, PhD
Full Professor, Department of Biochemistry & Molecular Biology, Cross-Appointment Department of Pathology
Director-Pipeline to Precision Medicine for Cancer
Dalhousie University Faculty of Medicine
Understanding how protein kinase and tumour suppressor proteins are involved in mediating disease.
Harnessing tumour suppressors against disease
Dr. Paola Marignani studies how protein kinases and tumour suppressor proteins are involved in mediating disease, in particular cancer. When functioning normally, these proteins prevent cancers from forming. Dr. Marignani and her research team have discovered that when the tumour suppressor kinase LKB1 is mutated, it becomes cancer-causing. These findings were published as a priority report in the prestigious journals, Cancer Research and Cancer Biology and Therapy. Using a system biology approach, Dr. Marignani has developed new technologies to discover novel LKB1 signalling networks. She has uncovered novel proteins that communicate with LKB1, shedding light on LKB1’s role in the development and progression of cancer. Her ultimate goal is to develop a strategy to repair damages to the LKB1 signalling network, thus allowing the tumour suppressor protein to regain a genomic surveillance cancer-fighting role.